Results 21 to 30 of about 5,625,610 (302)
Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response. [PDF]
PLoS Computational Biology, 2010 Mutators are clones whose mutation rate is about two to three orders of magnitude higher than the rate of wild-type clones and their roles in adaptive evolution of asexual populations have been controversial.
Muyoung Heo, Eugene I Shakhnovich
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Phenotypic heterogeneity in modeling cancer evolution. [PDF]
PLoS ONE, 2017 The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of
Ali Mahdipour-Shirayeh +3 more
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Linking Diversity and Differentiation
Diversity, 2010 Generally speaking, the term differentiation refers to differences between collections for the distribution of specified traits of their members, while diversity deals with (effective) numbers of trait states (types).
Hans-Rolf Gregorius
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Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry.
PLoS Genetics, 2022 Self-fertilisation is widespread among hermaphroditic species across the tree of life. Selfing has many consequences on the genetic diversity and the evolutionary dynamics of populations, which may in turn affect macroevolutionary processes such as ...
Lucas Marie-Orleach +2 more
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PLoS ONE, 2022 Significant advances have been made to understand the genetic basis of breast cancer. High, moderate and low penetrance variants have been identified with inter-ethnic variability in mutation frequency and spectrum. Genome wide association studies (GWAS)
M. Boujemaa +6 more
semanticscholar +1 more source
Dispersal and population structure at different spatial scales in the subterranean rodent Ctenomys australis [PDF]
, 2014 This study was funded by grants from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP5838), Agencia de Promoción Científica y Tecnológica de la Argentina (PICTO1-423, BID-1728/OC-AR), and the programme ECOS-Sud France/Argentina ...
Gaggiotti, Oscar E. +4 more
core +2 more sources
Biology Direct, 2011 Understanding the evolutionary plasticity of the genome requires a global, comparative approach in which genetic events are considered both in a phylogenetic framework and with regard to population genetics and environmental variables.
Levasseur Anthony, Pontarotti Pierre
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Muller's ratchet and mutational meltdowns [PDF]
, 1993 We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ...
Lynch, M. +8 more
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A practical genome scan for population-specific strong selective sweeps that have reached fixation. [PDF]
PLoS ONE, 2007 Phenotypic divergences between modern human populations have developed as a result of genetic adaptation to local environments over the past 100,000 years. To identify genes involved in population-specific phenotypes, it is necessary to detect signatures
Ryosuke Kimura +3 more
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The clarifying role of time series data in the population genetics of HIV.
PLoS Genetics, 2021 HIV can evolve remarkably quickly in response to antiretroviral therapies and the immune system. This evolution stymies treatment effectiveness and prevents the development of an HIV vaccine.
Alison F Feder +2 more
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