Results 61 to 70 of about 145,239 (247)

Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape. [PDF]

PLoS ONE, 2017
Stronger selection implies faster evolution-that is, the greater the force, the faster the change. This apparently self-evident proposition, however, is derived under the assumption that genetic variation within a population is primarily supplied by ...
Masahiko Ueda, Nobuto Takeuchi, Kunihiko Kaneko   +2 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Genetic structure and diversity of Calycolpus moritzianus (Myrtaceae) in the north-eastern Andes of Colombia

Revista Mexicana de Biodiversidad, 2021
The Arrayán tree (Calycolpus moritzianus) is an endemic species from northern South America and it is important for its potential in the medical and cosmetic industry.
Diego Alexander Hernández-Contreras, Franklin de Jesús Torres-Torres, Mauricio Figueroa-Lozano, Luis Roberto Sánchez-Montaño, Andrés Mauricio Posso-Terranova, Jaime Eduardo Muñoz-Flórez   +5 more
doaj   +1 more source

Population dynamics in compressible flows

, 2012
Organisms often grow, migrate and compete in liquid environments, as well as on solid surfaces. However, relatively little is known about what happens when competing species are mixed and compressed by fluid turbulence.
A. Kolmogorov, A. Kolmogorov, A. Kurganov, A. Martin, A.P. Martin, A.R. Robinson, A.R. Robinson, C. Torney, D. R. Nelson, D.R. Nelson, F. D’Ovidio, F. Peters, F. Toschi, F. Toschi, G. Boffetta, G. Boffetta, G. Falkovich, I.M. Held, J. Bec, J. Bec, J. Bec, J. ichi Wakita, J. Mannik, J.R. Cressman, K. Korolev, K. Mizobota, K.A. Dahmen, L. Biferale, L. Thomas, M. H. Jensen, M. Kimura, N.M. Shnerb, O. Hallatschek, O. Hallatschek, O. Hallatschek, P. Klein, P. Klein, P. Perlekar, P. Perlekar, R. Benzi, R. Benzi, R. Benzi, R. Fisher, S. Berti, S. Pigolotti, T. Neicu, T. Tel, W. McKiver, W. Saarloos van, W.J. McKiver, W.M. Durham, X. Capet   +51 more
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Epigenetics and Evolution: Transposons and the Stochastic Epigenetic Modification Model

AIMS Genetics, 2015
In addition to genetic variation, epigenetic variation and transposons can greatly affect the evolutionary fitnesses landscape and gene expression. Previously we proposed a mathematical treatment of a general epigenetic variation model that we called ...
Sergio Branciamore, Andrei S. Rodin, Grigoriy Gogoshin, Arthur D. Riggs   +3 more
doaj   +1 more source

The propagation of a cultural or biological trait by neutral genetic drift in a subdivided population

, 2007
We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological ...
Barton, Baxter, ben Avraham, Charlesworth, Cherry, Cox, Crow, Donnelly, Fisher, Gordon, Gradshteyn, Griffiths, Grimmett, Kelly, Kimura, Kingman, Latter, Lieberman, Maruyama, Maruyama, Moran, Möhle, Nagylaki, Nei, Nordborg, Notohara, Notohara, Peliti, R.A. Blythe, Rousset, Rousset, Rousset, Roze, Sjödin, Slatkin, Slatkin, Slatkin, Takahata, Trudgill, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Whitlock, Whitlock, Wilkinson-Herbots, Wright   +48 more
core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis

Evolutionary Applications, 2023
Understanding the genetic targets of natural selection is one of the most challenging goals of population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation ...
Alan Le Moan, Marina Panova, Aurélien De Jode, Olga Ortega‐Martinez, Mårten Duvetorp, Rui Faria, Roger Butlin, Kerstin Johannesson   +7 more
doaj   +1 more source

Exact results for fixation probability of bithermal evolutionary graphs

, 2012
One of the most fundamental concepts of evolutionary dynamics is the "fixation" probability, i.e. the probability that a mutant spreads through the whole population.
Houchmandzadeh, Bahram, Vallade, Marcel
core   +3 more sources