Results 61 to 70 of about 147,226 (247)
Revista Mexicana de Biodiversidad, 2021 The Arrayán tree (Calycolpus moritzianus) is an endemic species from northern South America and it is important for its potential in the medical and cosmetic industry.
Diego Alexander Hernández-Contreras +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Epigenetics and Evolution: Transposons and the Stochastic Epigenetic Modification Model
AIMS Genetics, 2015 In addition to genetic variation, epigenetic variation and transposons can greatly affect the evolutionary fitnesses landscape and gene expression. Previously we proposed a mathematical treatment of a general epigenetic variation model that we called ...
Sergio Branciamore +3 more
doaj +1 more source
, 2007 We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological ...
Barton +48 more
core +1 more source
The effects of recombination rate on the distribution and abundance of transposable elements [PDF]
, 2008 Transposable elements (TEs) often accumulate in regions of the genome with suppressed recombination. But it is unclear whether this pattern reflects a reduction in the efficacy of selection against deleterious insertions or a relaxation of ectopic ...
Charlesworth, Brian, Dolgin, Elie S.
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Evolutionary Applications, 2023 Understanding the genetic targets of natural selection is one of the most challenging goals of population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation ...
Alan Le Moan +7 more
doaj +1 more source
Exact results for fixation probability of bithermal evolutionary graphs
, 2012 One of the most fundamental concepts of evolutionary dynamics is the "fixation" probability, i.e. the probability that a mutant spreads through the whole population.
Houchmandzadeh, Bahram, Vallade, Marcel
core +3 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source