Results 61 to 70 of about 5,625,610 (302)

A population genetics model of marker-assisted selection [PDF]

, 1997
A deterministic two-loci model was developed to predict genetic response to marker-assisted selection (MAS) in one generation and in multiple generations.
Luo, Z. W., Woolliams, J. A., Luo, Z.W., Woolliams, John, Thompson, R.   +4 more
core  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Fixation probability in a diploid sexually reproducing population

bioRxiv
Classical population genetics models with haploid individuals and cloning reproduction, such as the Moran process, have limited power in predicting the evolutionary fate of mutants in diploid, sexually reproducing populations.
Zhe Shi, L. Marrec, X. Richter
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Population genetics in compressible flows. [PDF]

Physical Review Letters, 2011
We study competition between two biological species advected by a compressible velocity field. Individuals are treated as discrete Lagrangian particles that reproduce or die in a density-dependent fashion.
S. Pigolotti, R. Benzi, M. Jensen, D. R. Nelson   +3 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A new method for ecologists to estimate heterozygote excess and deficit for multi‐locus gene families

Ecology and Evolution
The fixation index, FIS, has been a staple measure to detect selection, or departures from random mating in populations. However, current Next Generation Sequencing (NGS) cannot easily estimate FIS, in multi‐locus gene families that contain multiple loci
Gabe D. O'Reilly, Oliver Manlik, Sandra Vardeh, Jennifer Sinclair, Belinda Cannell, Zachary P. Lawler, William B. Sherwin   +6 more
doaj   +1 more source

Numerical Solutions for Fractional Fixation Times in Evolutionary Models

Axioms
The fixation time of alleles is a fundamental concept in population genetics, traditionally studied using the Wright–Fisher model and classical coalescent theory.
Somayeh Mashayekhi
doaj   +1 more source

Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape. [PDF]

PLoS ONE, 2017
Stronger selection implies faster evolution-that is, the greater the force, the faster the change. This apparently self-evident proposition, however, is derived under the assumption that genetic variation within a population is primarily supplied by ...
Masahiko Ueda, Nobuto Takeuchi, Kunihiko Kaneko   +2 more
doaj   +1 more source