Results 121 to 130 of about 22,265 (348)

No Easy Fixes [PDF]

open access: yesNew England Journal of Medicine, 2013
Ms. D. has received 10 drug-eluting stents, primarily for atypical chest discomfort, with one stenting begetting another. In our system, it's somehow easier to provide 10 state-of-the-art stents than access to a generic pill and social, financial, and psychiatric support.
openaire   +2 more sources

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang   +8 more
wiley   +1 more source

To fix or not to fix? [PDF]

open access: yesJournal of Musculoskeletal Surgery and Research, 2019
openaire   +3 more sources

Microanalytical identification of barium sulphate crystals in statoliths of Chara Rhizoids [PDF]

open access: yes
In contrast to higher plants, Chara rhizoids contain statolith vacuoles filled with biocrystallites of BaS04 in the form of rods composed of globular subunits ca. 7 nm in diameter. The revelation of the crystallites under electron microscopy is dependent
Lauchli, A.   +2 more
core   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

open access: yesAdvanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang   +8 more
wiley   +1 more source

A study of mitochondrial membranes in relation to elementary particles [PDF]

open access: yes, 1967
Elementary particles that commonly have been seen by electron microscopy to be attached by stalks to mitochondrial cristae in negatively stained preparations, were not apparent in similarly stained mitochondria from exponentially growing wild-type ...
Eakin, R. T., Malhotra, S. K.
core  

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

open access: yesAdvanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang   +7 more
wiley   +1 more source

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

open access: yesAdvanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu   +18 more
wiley   +1 more source

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