Results 81 to 90 of about 20,193 (282)

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry, GF Bottazzo, GF Bottazzo, GS Eisenbarth, J Satoh, MA Atkinson, MR Christie, P Casali, PG Colman, R Gianani, RC Nayak, RJ Tuson, RL Sorenson, S Baekkeskov, S Baekkeskov, S Genovese, W Richter, W Richter, W Richter, WA Scherbaum   +19 more
core   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Expression of Epstein–Barr Virus–Encoded Small RNA (by the EBER-1 Gene) in Liver Specimens from Transplant Recipients with Post-Transplantation Lymphoproliferative Disease [PDF]

, 1992
Epstein-Barr virus (EBV)—associated post-transplantation lymphoproliferative disease (PTLD) develops in 1 to 10 percent of transplant recipients, in whom it can be treated by a reduction in the level of immunosuppression.
Anthony J. Demetris, Bush, Crouse, Demetris, Gowing, Hanto, Katz, Lawrence M. Weiss, Locker, Lukes, Markin, Michael Nalesnik, Nalesnik, Nilsson, Parmjeet S. Randhawa, Randhawa, Ronald Jaffe, Rooney, Schuurman, Sheibani, Shibata, Su, Thomas E. Starzl, Weiss, Weiss, Weiss, Yuan Yuan Chen   +26 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Effect of fixative type and fixation time on the morphology of bovine preantral ovarian follicles
Efeito do tipo de fixador e tempo de fixação na morfologia de folículos pré-antrais ovarianos bovinos

Semina: Ciências Agrárias, 2012
There are no efficient fixatives for histological analyses of ovarian tissue that permit an appropriate morphological analysis of ovary and their cells.
Rogerio Ferreira, Alethéia Ciquini, Carine Letícia Schneider, Livia Aires Lisboa, Evelyn Rabelo Andrade, Katia Cristina Silva-Santos, Joabel Tonellotto dos Santos, Janduí Escariao Nobrega Júnior, Marcelo Marcondes Seneda   +8 more
doaj   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Fixatives, Decalcifiers and Ultrastructure of the organic remnants from mural Nacreous Layers of Fossil Cephalopod Shells [PDF]

, 1983
The ultrastructure of the organic remnants has been compared in the TEM, after decalcification of the mural nacre of ammonites and fossil nautiloids by EDTA, which removes a soluble fraction, and after fixation and decalcification by formaldehyde-cetyl ...
Goffinet, G., Grégoire, Ch., Voss-Foucart, M.F.   +2 more
core  

Cleavable Crosslinkers as Tissue Fixation Reagents for Proteomic Analysis [PDF]

, 2018
Formaldehyde fixation is widely used for long-term maintenance of tissue. However, due to formaldehyde-induced crosslinks, fixed tissue proteins are difficult to extract, which hampers mass spectrometry (MS) proteomic analyses. Recent years have seen the
Baker, Bullen, Chan, Chaurand, Davalieva, de Graaf, Fowler, Fowler, Fowler, Gazziero, Hains, Kawashima, Klockenbusch, Kojima, Kothmaier, Longuespée, Lykidis, Maes, Magdeldin, Mange, Matsuda, Nietner, Ostasiewicz, Saitoh, Shi, Staff, Steiner, Tanca, Thompson, Vincenti, Vizcaíno, Wisniewski, Wisniewski, Zanini   +33 more
core   +5 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

A cross-sectional study to correlate nuclear fixative properties of formal saline and clarke’s fluid for histomorphology evaluation of human tissues

MRIMS Journal of Health Sciences
Background: Formal saline is an extensively used cheapest and easily available tissue fixative. However, formalin has been proven to have carcinogenic effects.
Lakshya Venugopal, Vasudha Kulkarni
doaj   +1 more source