Results 181 to 190 of about 452,734 (338)

A Topical Preservative-free Fixed-dose Combination Remedy in Patients with Glaucoma with Insufficient Response to Monotherapy – The VISIONARY Study [PDF]

, 2019
Francesco Oddone, IRCCS Fondazione G.B. Bietti, Rome, Italy   +1 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms

, 2018
Morton Scheinberg,1 Henrique Pott Júnior,2 Eduardo de Almeida Macêdo,2 Monalisa Fernanda Bocchi de Oliveira,2 Christina Ecclissato,2 Roberto Bleuel Amazonas2 1Clinical Research Center Hospital AACD, Hospital Israelita Albert Einstein, S ...
Scheinberg M, Amazonas RB, Macêdo EA, Ecclissato C, Bocchi de Oliveira MF, Pott Júnior H   +5 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Comparative effectiveness of a fixed-dose combination of losartan + HCTZ versus bisoprolol + HCTZ in patients with moderate-to-severe hypertension: results of the 6-month ELIZA trial

Vascular Health and Risk Management, 2013
GD Radchenko, YM Sirenko, SM Kushnir, OO Torbas, AS DobrokhodSecondary Hypertension Department, National Scientific Center, Strazhesko Institute of Cardiology, Kiev, UkraineBackground: The aim of this study was to compare the antihypertensive efficacy of
Radchenko GD, Sirenko YM, Kushnir SM, Torbas OO, Dobrokhod AS   +4 more
doaj  

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

, 2015
Sang-In Park,1,* Howard Lee,1,2,* Jaeseong Oh,1 Kyoung Soo Lim,3 In-Jin Jang,1 Jeong-Ae Kim,4 Jong Hyuk Jung,4 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul ...
Jang IJ, Lim KS, Oh J, Yu KS, Lee H, Jung JH, Park SI, Kim JA   +7 more
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Fixed-dose combinations: An essential for rational preparation

Indian Journal of Pharmacology, 2021
Thangaraju, Pugazhenthan, Varthya, Shoban Babu, Venkatesan, Sajitha   +2 more
openaire   +3 more sources

Effectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study

, 2023
Kwang Je Lee, Jae-Kean Ryu, Yun‐Hyeong Cho, Won Yong Shin, Jeong‐Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok‐Min Kang   +9 more
openalex   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source