Results 31 to 40 of about 10,047 (211)

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Automatic synthesis of analog layout : a survey [PDF]

, 1990
A review of recent research in the automatic synthesis of physical geometry for analog integrated circuits is presented. On introduction, an explanation of the difficulties involved in analog layout as opposed to digital layout is covered.
Rentmeesters, Mark J.
core  

Power Converters and Power Quality [PDF]

, 2015
This paper discusses the subject of power quality for power converters. The first part gives an overview of most of the common disturbances and power quality issues in electrical networks for particle accelerators, and explains their consequences for ...
Kahle, K.
core   +3 more sources

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Distribution System Voltage Management and Optimization for Integration of Renewables and Electric Vehicles: Research Gap Analysis [PDF]

, 2013
California is striving to achieve 33% renewable penetration by 2020 in accordance with the state’s Renewable Portfolio Standard (RPS). The behavior of renewable resources and electric vehicles in distribution systems is creating constraints on the ...
Arghandeh, Reza, Brown, Merwin, Cibulka, Lloyd, Miller, Larry, von Meier, Alexandra   +4 more
core  

BPS Branes in Cosmology

, 2001
The possibility to study the M/string theory cosmology via 5d bulk & brane action is investigated. The role of the 4-form field in the theory of BPS branes in 5d is clarified.
A. Ceresole, A. Lukas, A. Lukas, A. Lukas, A. Lukas, A. Lukas, A. Lukas, A. Lukas, A.A. Tseytlin, Andrei Linde, Arkady Tseytlin, B.R. Greene, C.P. Burgess, E. Bergshoeff, E. Bergshoeff, E. Bergshoeff, E. Witten, G. Dvali, G. Felder, G. Gibbons, G. Moore, G.W. Gibbons, G.W. Gibbons, H.P. Nilles, H.P. Nilles, I. Antoniadis, I. Antoniadis, J. Khoury, J. Maldacena, K. Behrndt, K. Benakli, L. Randall, L. Randall, Lev Kofman, N. Arkani-Hamed, N. Kaloper, O. DeWolfe, P. Binetruy, P. Brax, P. Hořava, P. Hořava, R. Kallosh, R. Kallosh, Renata Kallosh, T. Banks, W.D. Goldberger, Z. Lalak   +46 more
core   +1 more source

Spheromak Experiment Using Separate Guns For Formation And Sustainment [PDF]

, 1996
An experiment is described that incorporates the use of separate magnetized plasma guns for formation and sustainment of a spheromak. It is shown that energy coupling efficiency approaches unity if the gun and spheromak are of comparable size.
Brown, Michael R., Martin, A.
core   +2 more sources

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source