Results 51 to 60 of about 10,047 (211)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

BMEMat, EarlyView.
This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.
Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang   +9 more
wiley   +1 more source

The evidence base for ranger patrol effectiveness in conservation and how to improve it

Biological Reviews, EarlyView.
ABSTRACT Ranger patrols are a cornerstone of wildlife protection efforts around the world and occur across all ecological governance systems. Evidence that patrols reduce threats to wildlife and enable their recovery has not been systematically examined previously.
Trina Rytwinski, Robert S. A. Pickles, Matthew J. Muir, Steven J. Cooke, Joseph R. Bennett, Lisa A. Kelly, Adrienne Smith, Cynthia Cadet, Dwi N. Adhiasto, Inés Arroyo Quiroz, Mark D. Booton, Daphne P. Carlson, Drew T. Cronin, Anthony Dancer, Meredith L. Gore, Jennifer R. B. Miller, Stephen F. Pires, Amy Pokempner, James Slade, Andrew M. Lemieux   +19 more
wiley   +1 more source

Predictive control for energy management in all/more electric vehicles with multiple energy storage units [PDF]

, 2003
The paper describes the application of Model Predictive Control (MPC) methodologies for application to electric and hybrid-electric vehicle drive-train formats incorporating multiple energy/power sources.
Bingham, Chris, Schofield, N, West, M J
core  

Back to Nature or Technology to the Rescue? Climate Managers' Preferences for Investment in Carbon Dioxide Removal

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms are increasingly looking into carbon dioxide removal (CDR), a set of options to take past emissions of greenhouse gases out of the atmosphere. Often two basic categories of CDR are distinguished: nature‐based solutions, such as planting trees or restoring wetlands, and technology‐based solutions, such as various forms of carbon capture ...
Sabrina Mili, Robert Mai, Rolf Wüstenhagen, Moritz Loock   +3 more
wiley   +1 more source

Improving DRAM Performance by Parallelizing Refreshes with Accesses

, 2017
Modern DRAM cells are periodically refreshed to prevent data loss due to leakage. Commodity DDR DRAM refreshes cells at the rank level. This degrades performance significantly because it prevents an entire rank from serving memory requests while being ...
Alameldeen, Alaa R., Chang, Kevin K., Chishti, Zeshan, Kim, Yoongu, Lee, Donghyuk, Mutlu, Onur, Wilkerson, Chris   +6 more
core   +2 more sources

Key Challenges for Commercializing Perovskite–Silicon Tandem Solar Cells

Carbon Energy, EarlyView.
This review discusses the scientific and technological challenges in advancing perovskite–silicon tandem solar cells (PSTSCs) from lab‐scale to commercial viability, focusing on long‐term stability, scalability, and economic feasibility. Key issues include intrinsic and extrinsic degradation factors, installation conditions, environmental impacts, and ...
Bilal Mehmood, Yuanyuan Qin, Abdul Sattar, Rabeea Eman, Faheem Abbas, Shan Wu, Yipeng Xu, Xu Zheng, Jiangying Lu, Wei Jiang, Jiankai Liu, Shudi Lu, Shizhong Yue, Zhijie Wang, Kong Liu, Xiaopeng Zheng, Shengchun Qu   +16 more
wiley   +1 more source

Care and COVID 19: Lessons for liberals and neoliberals

Child &Family Social Work, EarlyView., 2023
Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley   +1 more source

AC OPF in Radial Distribution Networks - Parts I,II [PDF]

, 2015
The optimal power-flow problem (OPF) has played a key role in the planning and operation of power systems. Due to the non-linear nature of the AC power-flow equations, the OPF problem is known to be non-convex, therefore hard to solve.
Boudec, Jean-Yves Le, Christakou, Konstantina, Paolone, Mario, Tomozei, Dan-Cristian   +3 more
core   +1 more source

Mapping the Intellectual and Industrial Evolution of Corporate Social Responsibility: A Cross‐Sector Scientometric Analysis Using Main Path and Cluster Methods

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Corporate social responsibility (CSR) has undergone continuous expansion across industries, yet its intellectual evolution and cross‐sectoral linkages remain insufficiently understood. This study provides a comprehensive, data‐driven assessment of CSR's developmental trajectories by analyzing 3314 Web of Science articles using key‐route main ...
Wei‐Hao Su, Chia‐Chia Kuo, Long‐Sheng Chen   +2 more
wiley   +1 more source