Results 61 to 70 of about 1,034,399 (260)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An Enhanced Activated Zeroing Neural Dynamics for Solving Complex Matrix Inverse and Tracking Trajectory of Robotic Manipulator

IEEE Access
As an important branch of recurrent neural dynamics (RND), zeroing neural dynamics (ZND) can effectively deal with the dynamic complex matrix inverse (DCMI) issues.
Jialiang Chen, Yihui Lei, Bolin Liao
doaj   +1 more source

Generalized gamma approximation with rates for urns, walks and trees

, 2016
We study a new class of time inhomogeneous P\'olya-type urn schemes and give optimal rates of convergence for the distribution of the properly scaled number of balls of a given color to nearly the full class of generalized gamma distributions with ...
Peköz, Erol A., Ross, Nathan, Röllin, Adrian   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A fast fixed-time backstepping control method for systems with mismatched disturbances

Advances in Mechanical Engineering
In this paper, a fast fixed-time backstepping control approach is developed for systems with mismatched disturbances. A novel fast fixed-time disturbance observer (FFTDO), which is convergent within fixed time regardless of initial conditions, is ...
Huihui Pan, Hongwei Zhang, Peng Gao
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Fixed-Time Feedback Control of the Hydraulic Turbine Governing System

Complexity, 2018
Dealing with convergence time and dealing with steady state are two of the most challenging problems in the field of stability of the hydraulic turbine governing system.
Caoyuan Ma, Chuangzhen Liu, Xuezi Zhang
doaj   +1 more source

Continuous Fixed-Time Sliding Mode Attitude Controller Design for Rigid-Body Spacecraft

IEEE Access, 2020
Fast and high-precision attitude control for the rigid spacecraft is important for its broad applications in astronautics. In this paper, we address this problem via continuous nonsingular fixed-time sliding mode control approach.
Lei Wang, Zhuoyue Song
doaj   +1 more source

Shock fluctuations in flat TASEP under critical scaling

, 2014
We consider TASEP with two types of particles starting at every second site. Particles to the left of the origin have jump rate $1$, while particles to the right have jump rate $\alpha$.
Ferrari, Patrik L., Nejjar, Peter
core   +1 more source