Results 71 to 80 of about 1,034,399 (260)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Fixed-Time Target Tracking and Encirclement Control for Multi-UAVs with Bearing-Only Measurements

Drones
This paper introduces a novel fixed-time control framework for simultaneous target tracking and circumnavigation in a multi-UAV system, using only bearing measurements.
Zican Zhou, Jiangping Hu, Xuesong Wu, Shangzhi Liao, Jiao Yuan   +4 more
doaj   +1 more source

Anti-Unwinding Attitude Control with Fixed-Time Convergence for a Flexible Spacecraft

International Journal of Aerospace Engineering, 2017
This paper investigates the fixed-time attitude tracking control problem for flexible spacecraft with unknown bounded disturbances. First, with the knowledge of norm upper bounds of external disturbances and the coupling effect of flexible modes, a novel
Chutiphon Pukdeboon, Anuchit Jitpattanakul   +1 more
doaj   +1 more source

Robust fixed time controller with motor dynamics and composite disturbances for a quadrotor unmanned aerial vehicle

International Journal of Advanced Robotic Systems, 2020
A fixed time robust control method is presented for trajectory tracking control of quadrotor systems with motor dynamics in the presence of unmodeled disturbances and external disturbances. The recommended control method avoids the negative effect to the
Wei Shang, Shichao Hu, Xiao Li, Xikai Tu
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Improved Fixed-Time Attitude Tracking Control for Quadcopter Unmanned Aerial Vehicles

IEEE Access
Quadcopters have become a unmanned aerial vehicle class playing essential roles in a wide range of real-world applications. Many missions in such applications require the quadcopter’s attitude to converge to given setpoints in a fixed time ...
Xuan Nguyen, Sun Myung Won, Truong Dong do, Sung Kyung Hong   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Fixed-Time Event-Triggered Consensus of a Class of Multi-Agent Systems with Disturbed and Non-Linear Dynamics

Mathematics
This paper investigates the problem of fixed-time event-triggered consensus control for a class of multi-agent systems with disturbed and non-linear dynamics.
Yueqing Wang, Te Wang, Zhi Li
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Advances in ZNN Models for Solving Time-Varying Sylvester Equations: Convergence, Robustness, and Applications

IEEE Access
This article provides a systematic review of the specific field of solving time-varying Sylvester equations using zeroing neural network (ZNN), and delves into multi parameter joint sensitivity analysis and design strategies for the first time.
Xiangxiang Xi, Peng Miao, Yuheng Ding
doaj   +1 more source