Results 91 to 100 of about 44,754 (310)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Exploring the Response Mechanism of Remote Sensing Images in Monitoring Fixed Assets Investment Project in Terms of Building Detection

IEEE Access, 2019
Fixed assets investment is a driving factor in facilitating urbanization and economic growth. The local governments have spent a lot of budgets on the construction of fixed assets.
Li Wang, Wensheng Duan, Bo Yu, Qing Ying, Hanbing Yang, Yahui Lei   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Performance management of fixed assets

, 2015
Систематизовано поняття основних засобів, розглянуто багатогранність трактувань учених-економістів, наведено систему показників для оцінювання забезпеченості, стану та ефективності використання основних засобів, охарактеризовано методи оцінювання ...
Геращенко, Ірина Олексіївна, Стрижко, Олександр Андрійович   +1 more
core  

Problem issues of fixed assets accounting

UA: У статті досліджуються сучасні особливості обліку основних засобів, їх наявності та руху в умовах сьогодення бухгалтерського обліку та посилення ролі інформації в управлінні підприємством.
Голуб, Наталя Олександрівна, Golub, Natalia   +1 more
core   +1 more source

Structural analysis of national and regional economies against the mobility of tangible assets and the importance of secondary sector

Вестник Пермского университета: Серия Экономика
Introduction. No matter how much developed an economy is, it should have its own non-circulating tangible assets (in other words, its fixed assets), as well as labour force who could use these assets for their work.
Игорь Анохов
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Comparative Survey on the Records of Fixed Assets of Companies and Public Institutions

This paper deals by way of comparison with the theoretical and practical methods to record the output and input of tangible fixed assets (non-current assets) in and from the patrimony of companies, on the one side and of public institutions, on the other
Ecobici, Nicolae
core  

Depreciation of fixed assets

, 2016
Předložená práce je zaměřena na odepisování dlouhodobého majetku Západočeské univerzity v Plzni. Bakalářská práce obsahuje dvě části. V teoretické části je charakterizován fixní majetek v souvislosti s odpisy dlouhodobého majetku.
Kosnarová, Petra, Kadlecová, Pavla
core