Results 71 to 80 of about 44,754 (310)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Capitalization of Income Streams and the Effects of Open Market Policy under Fixed Exchange Rates [PDF]

open access: yes
This paper investigates the long- and short-run neutrality of open-market monetary policy in a world of fixed exchange rates and imperfect substitutability between bonds denominated in different currencies.
Maurice Obstfeld
core  

Analisis Aset Pemerintah Daerah Kota Bandung

open access: yesPublica, 2018
Local government assets are one of the elements of the regional government balance sheet. Asset informaton in the balance sheet, describes the conditons of economic wealth owned by the local government.
Rahayu Kusumadewi, Veren Virginia
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Analysis of Fixed Assets

open access: yes, 2009
The Bachelor thesis "The Analysis of Fixed Assets" focuses on the problems of fixed assets within the scope of the Czech legal enactments. The major goal of this thesis is not only the introduction of fixed assets in general, but mainly the analysis of ...
Hlaváčová, Jana
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Accounting for fixed assets

open access: yes, 1994
In a time of crumbling infrastructure, rising replacement costs, and a dwindling supply of capital, it is necessary to maximize the benefits of investment in long-term tangible assets.
Peterson, Raymond H.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Effect of Tax Facilities, Leverage, Transfer Pricing, Fixed Assets Intensity, and Political Power on Tax Management [PDF]

open access: yes, 2023
Tax management is a continuous concern. In addition to the fact that the corporation aims to maximize profits by minimizing its tax burden, tax management measures arise because the government and the company have different interests.
Tjeng, Prastika Suwandi
core  

CHARACTERISTICS OF TANGIBLE FIXED ASSETS REVALUATION

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2007
Evaluarea se referă la acea operaţiune de cuantificare, de măsurare în expresie valorică a bunurilor create, a resurse lor materiale, a cheltuielilor de muncă înmagazinate în produse, activităţi sau servicii executate.
USM ADMIN
doaj  

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