Results 121 to 130 of about 1,967,755 (312)

Raising Rivals' Fixed (Labor) Costs: The Deutsche Post Case [PDF]

open access: yes
We analyze the bargaining problem of an incumbent firm and a union when the wage contract becomes generally binding. Our main application relates to competition among operators of mail delivery networks.
Christian Wey, Sven Heitzler
core  

Hub facility location with fixed costs

open access: yesPapers in Regional Science, 1992
In thep-hub location model, it is usual to ignore the fixed costs of opening facilities. In contrast, the simple plant location problem includes fixed facility costs and thereby makes thenumber of facilities one of the decision variables. This paper introduces fixed facility costs into a hub location model, thereby making the number of hubs a decision ...
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Integrating econimic costs into the analysis of flexible conservation management strategies [PDF]

open access: yes
Flexible conservation management, where measures are selected in each decision period and depending on the current state of the ecological system, are generally perceived as superior to fixed management, where the same measure is applied in each decision
Drechsler, Martin   +3 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Allocation of fixed costs and the weighted Shapley value [PDF]

open access: yes
The weighted value was introduced by Shapley in 1953 as an asymmetric version of his value. Since then several approximations have been proposed including one by Shapley in 1981 specifically addressed to cost allocation, a context in which weights appear
DEHEZ, Pierre
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

A Model-Based Approach for Optimal Price Calculation of Primary Wood Products

open access: yesDrvna Industrija
During a period of intensive changes in the market, when profits cannot be increased by raising sales prices, companies focus on improving production processes and reducing costs.
Andreja Pirc Barčić   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

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