Results 41 to 50 of about 358,266 (307)

STUDY ABOUT THE ROAD TRANSPORTATION COSTS AND FISCALITY IN THE ROMANIAN COMPANIES [PDF]

open access: yesRisk in Contemporary Economy, 2013
The economic development of the European countries in the second half of the XXth century, and also the increase of commercial international exchanges, generated the transportation development in general, and especially the road transportation.
Violeta Isai, Riana Iren Radu
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The link between the optimal size of the firm and the break-even point in neoclassical theory

open access: yesУченые записки Российской академии предпринимательства, 2021
In conditions of complicated market situation and declining demand indexes of production efficiency lose their relevance as production output falls. For this situation it is suggested to consider the behavior of the company (corporation) within the break-
D. A. Maksimov   +2 more
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Forest road planning considering road and skidding costs (Case study: Kheyrud Forest) [PDF]

open access: yesمجله جنگل ایران, 2011
Hyrcanian forests are the only forests designated for commercial timber production inIran. Ground-based skidding is the most common timber harvesting system used in these forests, but due to low road density (1-2m/ha), large parts of the forests are ...
doaj  

A Simple Heuristic Approach for Step Fixed Charge Bulk Transportation Problem [PDF]

open access: yesInternational Journal of Mathematical, Engineering and Management Sciences
The classical transportation problem (CTP) is a particular kind of optimization problem. It involves determining the most cost-effective way to transport a uniform product from several suppliers (sources) to several consumers (destinations).
Shivani, Sudhir Kumar Chauhan, Renu Tuli
doaj   +1 more source

Impact of Fixed-Duration Oral Targeted Therapies on the Economic Burden of Chronic Lymphocytic Leukemia in Canada

open access: yesCurrent Oncology, 2023
Background: Continuous oral targeted therapies (OTT) represent a major economic burden on the Canadian healthcare system, due to their high cost and administration until disease progression/toxicity.
Jean Lachaine   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Fixed costs matter even when the costs are sunk [PDF]

open access: yes, 2020
How firms set prices is key to understanding markets. Standard economics dictates that the fixed costs of a firm should not affect its prices. Nonetheless, it is common practice for firms to raise their prices after a fixed costs increase.
Mendys-Kamphorst, E. (Ewa)   +5 more
core   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

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