Results 61 to 70 of about 358,266 (307)

Predicting Operating Income via a Generalized Operating-Leverage Model

International Journal of Financial Studies
We propose a generalized, practitioner-oriented operating-leverage model for predicting operating income using net sales, cost of sales, depreciation, and SG&A.
Sherwood Lane Lambert, Kevin Krieger, Nathan Mauck   +2 more
doaj   +1 more source

Operational risk management in financing environmental activities and personnel management projects [PDF]

E3S Web of Conferences, 2019
Projects on environmental protection and personnel management have a significant impact on the level of fixed costs and changes in operational risks of industrial enterprises.
Bril Aleksandr, Kalinina Olga, Kankovskaya Alina, Vilken Viktoria   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Annual Maintenance Costs of Draft Horses as a Part of Fixed Costs in Horse-Powered Agriculture: A Case Study from Požega, Croatia

Proceedings
The aim of this research is to estimate the fixed costs of the maintenance of draft horses in a low-input farm. Research has revealed that in the investigated case, the fixed costs of maintenance of three draft mares were EUR 5115.39 annually, with human
Ranko Gantner, Igor DelVechio, Zvonimir Steiner, Maja Gregić, Vesna Gantner   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Relationship between Sparseness and Energy Consumption of Neural Networks

Neural Plasticity, 2020
About 50-80% of total energy is consumed by signaling in neural networks. A neural network consumes much energy if there are many active neurons in the network. If there are few active neurons in a neural network, the network consumes very little energy.
Guanzheng Wang, Rubin Wang, Wanzeng Kong, Jianhai Zhang   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Fixed Costs and Long-Lived Investments [PDF]

Neoclassical investment models predict that firms should make frequent, small adjustments to their capital stocks. Microeconomic evidence, however, shows just the opposite -- firms make infrequent, large adjustments to their capital stocks.
Christopher L. House
core  

Supplier Fixed Costs and Retail Market Monopolization [PDF]

, 2014
Considering a vertical structure with perfectly competitive upstream firms that deliver a homogenous good to a differentiated retail duopoly, we show that upstream fixed costs may help to monopolize the downstream market.
Caprice, Stéphane, von Schlippenbach, Vanessa, Wey, Christian   +2 more
core   +1 more source

CONSIDERATIONS ON THE RATIONAL IMPUTATION OF THE FIXED EXPENSES [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2009
In this material we tried to address some issues relating to the rational allocation of fixed expenses, which is the elimination of complete calculation of costs of products, works or services variations in the incidence of activity.
Maria SANDU , Rodica BADIŢĂ
doaj