Results 61 to 70 of about 1,982,117 (353)

Fixed Transport Costs and International Trade [PDF]

open access: yesSSRN Electronic Journal, 2006
We develop a simple two country model of international trade that assumes that there is a fixed cost of doing international trade. We show that this leads to multiple equilibria that can be Pareto-ranked. We examine the stability properties of these equilibria.
Didier Laussel, Raymond Riezman
openaire   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Model for Determining Fixed Costs for the Winter Service Operation

open access: yesPromet (Zagreb), 2006
From the season 2005!06 a new dynamic model for the operationof the Winter Service in the Republic of Croatia will beused. The old model was based on three levels of readiness, andthe roads were categorised primarily according to their ...
Matija Glad   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Operational risk management in financing environmental activities and personnel management projects [PDF]

open access: yesE3S Web of Conferences, 2019
Projects on environmental protection and personnel management have a significant impact on the level of fixed costs and changes in operational risks of industrial enterprises.
Bril Aleksandr   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Relationship between Sparseness and Energy Consumption of Neural Networks

open access: yesNeural Plasticity, 2020
About 50-80% of total energy is consumed by signaling in neural networks. A neural network consumes much energy if there are many active neurons in the network. If there are few active neurons in a neural network, the network consumes very little energy.
Guanzheng Wang   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Determination of Total Costs, Labour Requirements and Work Efficiencies in Second Fodder Corn Silage Production at Bafra Town of Samsun

open access: yesTurkish Journal of Agriculture: Food Science and Technology, 2016
This study was completed with the aim of determining work efficiencies, labour requirement, and total cost of second fodder corn silage agricultural enterprises on flat ground in Bafra district of Samsun province. According to the results, total variable
Taner Yıldız
doaj   +1 more source

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