Results 161 to 170 of about 6,000,123 (363)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Balancing stability and flexibility: investigating a dynamic <i>K</i> value approach for the Elo rating system in adaptive learning environments. [PDF]

User Model User-adapt Interact
Vermeiren H, Hofman AD, Bolsinova M, van der Maas HLJ, Van Den Noortgate W.   +4 more
europepmc   +1 more source

Homomorphisms and derivations in "Equation missing" -ternary algebras via fixed point method [PDF]

, 2012
H.M. Kenari, Reza Saadati, Choonkil Park
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A novel approach to coincidence point results via proximal contractions with application. [PDF]

Sci Rep
Ahmad H, Ishtiaq U, Akram M, Popa IL.
europepmc   +1 more source

Iterative methods for split variational inclusion and fixed point problem of nonexpansive semigroup in Hilbert spaces [PDF]

, 2015
Dao-Jun Wen, Yi‐An Chen
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Improved deformation reconstruction of composite material structures based on optical fiber sensing. [PDF]

Sci Rep
Huang J, Sun Y, Peng Y, Zhang D, Li R, Yin S, Peng Z, Huang Q, Liu Q.   +8 more
europepmc   +1 more source

A globalized inexact semismooth Newton method for nonsmooth fixed-point equations involving variational inequalities [PDF]

Amal Alphonse, Constantin Christof, Michael Hintermüller, Ioannis P. A. Papadopoulos, Amal Alphonse, Constantin Christof, Michael Hintermüller, Ioannis P. A. Papadopoulos   +7 more
openalex   +1 more source

Monotone variational inequalities, generalized equilibrium problems and fixed point methods [PDF]

, 2014
Shenghua Wang
openalex   +1 more source