Results 41 to 50 of about 1,436,537 (316)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A parallel hybrid accelerated extragradient algorithm for pseudomonotone equilibrium, fixed point, and split null point problems

Advances in Difference Equations, 2021
This paper provides iterative construction of a common solution associated with the classes of equilibrium problems (EP) and split convex feasibility problems.
Yasir Arfat, Poom Kumam, Muhammad Aqeel Ahmad Khan, Parinya Sa Ngiamsunthorn, Attapol Kaewkhao   +4 more
doaj   +1 more source

Simultaneous Algorithms for Solving Split Equality Fixed Point Problems for Demicontractive Mappings [PDF]

, 2022
Abbas Umar Saje, L. B. Mohammed, Abba Auwalu   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

New Existence Results for Fixed Point Problem and Minimization Problem in Compact Metric Spaces

Abstract and Applied Analysis, 2014
We first present some new existence theorems for fixed point problem and minimization problem in compact metric spaces without assuming that mappings possess convexity property.
Weng-Seng Heng, Wei-Shih Du, Chi-Lin Yen
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Iterative Algorithms for the Split Problem and Its Convergence Analysis

Abstract and Applied Analysis, 2014
Now, it is known that the split common fixed point problem is a generalization of the split feasibility problem and of the convex feasibility problem. In this paper, the split common fixed point problem associated with the pseudocontractions is studied ...
Zhangsong Yao, Arif Rafiq, Shin Min Kang, Li-Jun Zhu   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Critical Theory of Non-Fermi Liquid Fixed Point in Multipolar Kondo Problem

Physical Review X, 2020
When the ground state of a localized ion is a non-Kramers doublet, such localized ions may carry multipolar moments. For example, Pr^{3+} ions in a cubic environment would possess quadrupolar and octupolar, but no magnetic dipole, moments.
Adarsh S. Patri, Yong Baek Kim
doaj   +1 more source

Modified Krasnoselski–Mann iterative method for hierarchical fixed point problem and split mixed equilibrium problem

Journal of Inequalities and Applications, 2020
In this paper, we introduce a modified Krasnoselski–Mann type iterative method for capturing a common solution of a split mixed equilibrium problem and a hierarchical fixed point problem of a finite collection of k-strictly pseudocontractive nonself ...
Jong Kyu Kim, Prashanta Majee
doaj   +1 more source