Results 111 to 120 of about 4,429,117 (277)
Extremal fixed points and Diophantine equations
Journal of High Energy PhysicsThe coupling constants of fixed points in the ϵ expansion at one loop are known to satisfy a quadratic bound due to Rychkov and Stergiou. We refer to fixed points that saturate this bound as extremal fixed points.
Christopher P. Herzog +3 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Asymptotic stability results for certain integral equations
Electronic Journal of Differential Equations, 2005 This paper shows the existence of asymptotically stable solutions to an integral equation. This is done by using a fixed point theorem, and without requiring that the solutions be bounded.
Cezar Avramescu, Cristian Vladimirescu
doaj
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fixed points for planar maps with multiple twists, with application to nonlinear equations with indefinite weight. [PDF]
Philos Trans A Math Phys Eng Sci, 2021 Margheri A, Rebelo C, Zanolin F.
europepmc +1 more source
Isolated elliptic fixed points for smooth Hamiltonians
We construct on $\R^{2d}$, for any $d \geq 3$, smooth Hamiltonians having an elliptic equilibrium with an arbitrary frequency, that is not accumulated by a positive measure set of invariant tori.
Fayad, Bassam, Saprykina, Maria
core