Results 141 to 150 of about 4,429,117 (277)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Fixed points of multivalued convex contractions with application. [PDF]

PLoS One
Khan AR, Al-Sulami HH, Rashid M, Shabbir F.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

New fixed points of mixed monotone operators with applications to nonlinear integral equations. [PDF]

PLoS One
Xu S, Han Y, Lin S, Zhou G.
europepmc   +1 more source

Stabilization of Weakly Unstable Fixed Points as a Common Dynamical Mechanism of High-Frequency Electrical Stimulation. [PDF]

Sci Rep, 2020
Wilson D.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Space temperature traceability based on near-site transfer of miniature fixed points. [PDF]

Commun Eng
Sima R, Hao X, Song J, Ling L, Zhou J, Qi H, Gu M, Ding L.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Fixed points of two interpolative cyclic contractions in b-metric spaces. [PDF]

Heliyon
Devi D, Debnath P.
europepmc   +1 more source

From Moral Fixed Points to Epistemic Fixed Points

, 2018
In a recent paper Terence Cuneo and Russ Shafer-Landau argue that there are moral conceptual truths that are substantive in content, what they called “moral fixed points.” I argue that insofar as we have some reason to postulate moral fixed points, we have equal reason to postulate epistemic fixed points (e.g. the factivity condition).
openaire   +2 more sources