Results 151 to 160 of about 4,586,045 (294)
, 2010 We propose a method to characterize the fixed points described in Tarski's theorem for complete lattices. The method is deductive: the least and greatest fixed points are "proved" in some inference system defined from deduction rules. We also apply the method to two other fixed point theorems, a generalization of Tarski's theorem to chain-complete ...
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Zeroes of holomorphic vector fields and Grothendieck duality theory (and applications to the holomorphic fixed-point formula of Atiyah and Bott) [PDF]
The holomorphic fixed-point formula of Atiyah and Bott is discussed in terms of Grothendieck's theory of duality for algebraic varieties. The treatment is valid for an endomorphism of a compact complex-analytic manifold with arbitrary isolated fixed ...
O'Brian, Nigel Robert
core
Nonequilibrium Fixed Points of Coupled Ising Models. [PDF]
Phys Rev X, 2020 Young JT +3 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Computing and optimizing over all fixed-points of discrete systems on large networks. [PDF]
J R Soc Interface, 2020 Riehl JR +4 more
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Structural Entanglement from Interaction-Induced Fixed Points. [PDF]
Entropy (Basel)Gunji YP, Khrennikov A.
europepmc +1 more source