Results 21 to 30 of about 32,830 (230)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Quais são os benefícios do uso de vernizes fluoretados? [PDF]
, 2014 Analisa os benefícios do uso de vernizes fluoretados para prevenção e/ou redução de cáries, apresentando resultados de revisões sistemáticas acerca da utilização de flúor na redução de ...
Núcleo Telessaúde Estadual do Rio Grande do Sul
core
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Revista Facultad de Odontología Universidad de Antioquia, 1993 La presente investigación constituye la parte II de una línea tendiente a definir si hay absorción por mucosa bucal del flúor utilizado en enjuagues para prevenir la caries dental, lo cual expliaría la sobredosis de éste, detectada en orina 4 horas ...
Fanny Lucía Yepes Delgado +2 more
doaj
Problemática de las emisiones de flúor, cloro y azufre durante la cocción de materiales de la industria ladrillera. [PDF]
, 1998 proceso de cocción de materias primas cerámicas lleva implícito la emisión de elementos contaminantes (F, Cl, SO2, B, NOx ). En el caso de emisiones de F, Cl, y S la contaminación depende de la concentración de estos elementos en las materias primas ...
Fabbri, Bruno +2 more
core
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Revista Facultad de Odontología Universidad de Antioquia, 1992 Con el propósito de determinar presencia de flúor sistémico después de la aplicación de los enjuagues con fluoruro de sodio al 2% en niños en edad escolar, se hizo análisis de flúor en la orina de dos grupos de niño: experimental y control.
Fanny Lucía Yepes Delgado +2 more
doaj
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Avaliação do Teor de Flúor na Água de Abastecimento e sua Retenção pelos Filtros Domésticos
Revista da Faculdade de Odontologia de Porto Alegre, 2008 O objetivo deste trabalho foi verificar o teor de flúor da água de abastecimento nas residências, analisar se ocorre alteração no nível de flúor após a água passar pelos reservatórios e filtros domésticos.
Virgílio Vilas Boas Fernandes JR +4 more
doaj +3 more sources