Results 41 to 50 of about 338,159 (191)

Concentración de flúor y arsénico en el agua de red de General Pico (Argentina) durante el periodo 2007-2013/ Fluor and Arsenic concentration in tap water of General Pico from the period of 2007 to 2013

Ciencia Veterinaria, 2017
La provincia de La Pampa (Argentina) se caracteriza por presentar en sus aguas subterráneas alta concentración de arsénico y flúor. En este trabajo, se determinó la concentración de flúor y arsénico en el agua de red que llega a los habitantes de la ...
Alberto Oscar Pariani, José Manuel Perea Muñoz, Ariel Osvaldo Castaldo, Antón Rafael García Martinez, Alberto Osvaldo Giorgis, Elena Angón Sanchez de Pedro, Priscila Gisela Lamela Arteaga, F. Hecker   +7 more
doaj  

Fluorosis dental en zonas volcánicas: análisis de factores asociados en una población escolar colombiana

Biomédica: revista del Instituto Nacional de Salud
Introducción. La fluorosis dental es un problema endémico en el sur de Colombia, especialmente por su cercanía a zonas volcánicas y la composición de sus aguas. Objetivo.
Yeimy Tatiana Ortega, Angye Paola Salcedo, Rafaela Reis da Silva, Bruno Gutiérrez, Johana Alejandra Moreno   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

INVESTIGAÇÃO DO USO DE POLIVITAMÍNICOS COMO POSSÍVEL CAUSA DE FLUOROSE EM CRIANÇAS

Colloquium Vitae, 2009
Este trabalho teve por objetivo investigar as causas da fluorose dando enfoque principal à presença de flúor nos polivitamínicos. Foram avaliadas crianças com fluorose coletando dados referente à história pregressa de utilização de fluoretos, como o uso ...
Eliane C Gava Pizi, Cristiane Carvalho Luiz, Sílvia Fabrício   +2 more
doaj  

Ten years of external control of the fluoride level in public drinking water provided by Brazilian cities, Brazil, 1996-2006 [PDF]

RGO: Revista Gaúcha de Odontologia, 2008
Objective: To evaluate the program of external control of water fluoridation performed in the periods between 1996 and 2006 by ten cities: eight in the State of São Paulo, one in Minas Gerais and another in the State of Ceará.
Jaime Aparecido Cury, Maria da Luz Rosário de Souza, Carolina de Oliveira, Regiane Cristina do Amaral, Danilo Bonadia Catani   +4 more
doaj  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source