Results 51 to 60 of about 331,423 (196)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Prevalência e severidade de fluorose dentária em escolares de 12 e 13 anos de idade de Florianópolis, SC, 2011 [PDF]

open access: yes, 2013
TCC- Universidade Federal de Santa Catarina, Centro de ciências da saúde, OdontologiaO objetivo deste estudo foi determinar a prevalência e severidade de fluorose dentária, bem como verificar as possíveis relações com sexo e idade, de escolares de 12 e ...
Silveira, Luiz Fernando Monteiro
core  

Liberación De Ion Flúor En Selladores De Fosetas Y Fisuras [PDF]

open access: yes, 2023
Introducción: La caries dental es la patología bucal más común tanto en incidencia como en prevalencia. Se ha demostrado que más del 95% de la población mundial la padece y que el 30% de todas las lesiones cariosas se originan en puntos y fisuras ...
Martínez Melesio, José Iván   +1 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Comparación de la cantidad de flúor en las pastas dentales comercializadas en Perú - 2022 [PDF]

open access: yes, 2023
Objetivos: Determinar la diferencia en la cantidad de flúor de las pastas dentales comercializadas en Perú – 2022. Material y método: El estudio fue cuantitativo, básico, descriptivo y correlacional, prospectivo, transversal, de campo y no ...
Jallurana Añamuro, Ramiro
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Samantekt um flúor

open access: yes, 2010
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open)Umræða um gagnsemi flúors í tannvernd er ekki ný af nálinni en virkni flúors gegn tannátu hefur verið þekkt í rúma hálfa öld.
Hólmfríður Guðmundsdóttir
core  

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