Results 111 to 120 of about 996,228 (285)
Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration
Advanced Science, EarlyView.Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin +7 more
wiley +1 more source
中国工程科学Heredity underlies the stability of an organism’s fundamental phenotype. The complex interaction between genetic variation, epigenetic modification, microbial and environmental factors, and biological inheritance determines the phenotypic differences of ...
Chen Wei
doaj +1 more source
The newspaper K'inhyegaman bayrakh (the flag of labour) for displaced persons: typological features
, 2022 L. A. Turpalov
openalex +2 more sources
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Endocrine JournalPaeoniflorin (Pae) can improve diabetes mellitus (DM), especially endothelial dysfunction induced by high glucose (HG). Molecularly, the mechanism pertinent to Pae and DM lacks further in-depth research.
Wenting Yu, Hongchun Jiang
doaj +1 more source
Validating the presence of Spanish Flag, Gonioplectrus hispanus (Cuvier, 1828) (Perciformes, Serranidae), from the south-western Gulf of Mexico [PDF]
, 2021 Luis Fernando Del Moral-Flores +3 more
openalex +1 more source
Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling
Advanced Science, EarlyView.ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li +12 more
wiley +1 more source
Universal Gysin formulas for flag bundles [PDF]
, 2017 Lionel Darondeau, Piotr Pragacz
openalex +1 more source
Advanced Science, EarlyView.RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng +6 more
wiley +1 more source
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
Advanced Science, EarlyView.NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source