Results 151 to 160 of about 326,725 (317)

1848-12-14 Kentucky Flag

Kentucky Flag published on December 14 ...
Kentucky Flag (Maysville, Ky.)
core  

Genetic identification and characterization of novel loci for flag leaf morphology traits in Chinese endemic wheat. [PDF]

Plant Genome
Lohani MN, Su L, Lu L, Yin L, Liu Y, Xu Q, Jiang Y, Jiang Q, Chen G, Wei Y, Liu C, Xie Q, Ma J.   +12 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

1849-01-31 Kentucky Flag

Kentucky Flag published on January 31 ...
Kentucky Flag (Maysville, Ky.)
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Developing a standard definition for sequences of concern. [PDF]

Front Bioeng Biotechnol
Alexanian T, Beal J, Bartling C, Berlips J, Carr PA, Clore A, Cozzarini H, Diggans J, El Moubayed Y, Esvelt K, Flyangolts K, Foner L, Fullerton PA, Gemler BT, Jagla CAD, Lababidi R, Mitchell T, Murphy ST, Parker MT, Roehner N, Rusch A, Talley K, Timmerman T, Wheeler NE.   +23 more
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

1848-01-26 Kentucky Flag

Kentucky Flag published on January 26 ...
Kentucky Flag (Maysville, Ky.)
core  

Can artificial intelligence transform higher education?

International Journal of Educational Technology in Higher Education, 2020
Tony Bates, Cristóbal Cobo, Olga Mariño, Steve Wheeler   +3 more
doaj   +1 more source

AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling. [PDF]

Front Immunol
Mi S, Zhu Y, Li Q, Wang X, Guo X, Chen Y.   +5 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source