Results 161 to 170 of about 369,120 (314)

Investigating Translocation Mechanisms of TDP-43 Into the Endoplasmic Reticulum Using Budding Yeast Models. [PDF]

Traffic
Saito M, Tsuzuki H, Hosomi A.
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

1848-04-05 Kentucky Flag [PDF]

Kentucky Flag published on April 5 ...
Kentucky Flag (Maysville, Ky.)
core  

ATG13 promotes K63-linked polyubiquitination of MAVS via ASB1 to restrict influenza A virus replication. [PDF]

Emerg Microbes Infect
Lu Y, Chen J, Xiao H, Li J, Wang H, Liang T, Wang J, Pang X, Cheng M, Sun Y, Cui T, Pu F, Zhan J, Zhao Y, Bao H, Yang W, Jiang Y, Yang G, Wang J, Cao X, Wang C, Bai X, Zeng Y.   +22 more
europepmc   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

1848-07-19 Kentucky Flag [PDF]

Kentucky Flag published on July 19 ...
Kentucky Flag (Maysville, Ky.)
core  

Predictors of Hospital Admission and Cardiac Diagnosis in Children Presenting with Chest Pain: The Role of Recurrent Presentation and Inflammatory Markers. [PDF]

Medicina (Kaunas)
Demir Ş, Ayar M, Doğan AN, Çağlar A.
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

1848-08-30 Kentucky Flag [PDF]

Kentucky Flag published on August 30 ...
Kentucky Flag (Maysville, Ky.)
core  

A feline coronavirus nucleocapsid protein disrupts ZC3HAV1-viral RNA association to counteract host RNA-level restriction. [PDF]

PLoS Pathog
Zhang M, Li N, Aishanjiang K, Tang A, Zhu M, Zhu S, Zhang D, Yu L, Zhu J, Li C, Meng C, Zhu Y, Li G, Liu G.   +13 more
europepmc   +1 more source