Results 171 to 180 of about 326,725 (317)
The role of FMR1 mRNA structure on the efficiency of non-canonical translation of toxic polyglycine protein. [PDF]
Nucleic Acids ResNiewiadomska D +4 more
europepmc +1 more source
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER. [PDF]
iScienceWada S, Uegaki K, Nagata K, Ushioda R.
europepmc +1 more source
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
NEK2A regulates PLIN2 expression through a SERBP1 dependent pathway. [PDF]
iScienceMakiyama T +8 more
europepmc +1 more source
Advanced Science, EarlyView.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]
ElifeXiang Q +11 more
europepmc +1 more source