Results 171 to 180 of about 369,120 (314)

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

1848-06-30 Campaign Flag [PDF]

Campaign Flag published on June 30 ...
Campaign Flag (Maysville, Ky.)
core  

Can artificial intelligence transform higher education?

International Journal of Educational Technology in Higher Education, 2020
Tony Bates, Cristóbal Cobo, Olga Mariño, Steve Wheeler   +3 more
doaj   +1 more source

Discovering host-viral protein interactions in autophagy: A LIR discovery pipeline for identifying LC3-interacting region motifs in highly virulent viruses. [PDF]

PLoS Pathog
Petraccione KD, Wahba HM, Ali MGH, Stocker T, Akhrymuk I, Swese Y, Sastre D, Silberfarb A, O'Maille PE, Omichinski JG, Kehn-Hall K.   +10 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

1848-02-23 Kentucky Flag [PDF]

Kentucky Flag published on February 23 ...
Kentucky Flag (Maysville, Ky.)
core  

CERES forms a complex with RH37 and eIF4E. [PDF]

Plant Cell Rep
Okeke IC, Muñoz A, Castellano MM.
europepmc   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

1848-01-05 Kentucky Flag [PDF]

Kentucky Flag published on January 5 ...
Kentucky Flag (Maysville, Ky.)
core  

The OsUVR8-OsNAC3-OsERF117 signaling module mediates metabolic acclimation and climate adaptation in rice. [PDF]

Sci Adv
Liu W, Zhou D, Xing J, Xue S, Wang TJ, Guo P, Liu Y, Xu ZY.   +7 more
europepmc   +1 more source