Results 71 to 80 of about 1,081,696 (319)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Phenotyping of field-grown wheat in the UK highlights contribution of light response of photosynthesis and flag leaf longevity to grain yield

Journal of Experimental Botany, 2017
Flag leaf longevity and operating photosynthetic rates at ambient CO2 and a range of light levels correlated with grain yield of UK field-grown wheat, revealing new targets to enhance crop productivity.
Elizabete Carmo‐Silva, Elizabete Carmo‐Silva, P. J. Andralojc, Joanna C. Scales, S. Driever, S. Driever, A. Mead, T. Lawson, C. Raines, M. Parry, M. Parry   +10 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Aufgelöste historische Rechtsnormen und Gegenwart

Studia Historica Brunensia, 2015
This article describes the development of crests of cities and small towns with a particular focus on the crests of villages before 1990, when the municipal laws were published.
Ivan Štarha
doaj  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Quiver flag varieties and multigraded linear series

, 2010
This paper introduces a class of smooth projective varieties that generalise and share many properties with partial flag varieties of type A. The quiver flag variety M_\vartheta(Q,r) of a finite acyclic quiver Q (with a unique source) and a dimension ...
Craw, Alastair
core   +1 more source

Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm

Orphanet Journal of Rare Diseases, 2018
Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent ...
Y. Sekijima, M. Ueda, H. Koike, S. Misawa, T. Ishii, Y. Ando   +5 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

How to construct a flag complex with a given face vector [PDF]

, 2011
A method that often works for constructing a flag complex with a specified face vector is given. This method can also be adapted to construct a vertex-decomposable (and hence Cohen-Macaulay) flag complex with a specified h ...
Frohmader, Andrew
core  

Cycle Connectivity and Automorphism Groups of Flag Domains

, 2014
A flag domain $D$ is an open orbit of a real form $G_0$ in a flag manifold $Z=G/P$ of its complexification. If $D$ is holomorphically convex, then, since it is a product of a Hermitian symmetric space of bounded type and a compact flag manifold, ${Aut}(D)
A. Huckleberry, J. Brun
core   +1 more source