Results 41 to 50 of about 37,257 (258)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Sigma models on flags

SciPost Physics, 2019
We study (1+1)-dimensional non-linear sigma models whose target space is the flag manifold $U(N)\over U(N_1)\times U(N_2)\cdots U(N_m)$, with a specific focus on the special case $U(N)/U(1)^{N}$.
Kantaro Ohmori, Nathan Seiberg, Shu-Heng Shao
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Flag

Colombia Medica, 2017
Información general de la Revista Colombia ...
openaire   +3 more sources

Neuroimaging of patients with headache in the pediatric emergency department: A single center retrospective study

Pediatrics and Neonatology
Background: Headache is a common neurologic complaint in children and adolescents, and the secondary causes of headache in these patients should be identified and excluded.
Donghyun Shin, Yoo Jung Lee, Yoon Hee Jo, Juhyun Kong, Yun-Jin Lee, Sang Ook Nam, Young Mi Kim   +6 more
doaj   +1 more source

إستخدام إشارات خطر المراجعة ( Red Flags ( فى الکشف والتنبؤ بالتعثر المالى بمنظمات الأعمال [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-Tiğāriyyaẗ, 2018
وتتضح المشکلة فى التعرف على مدى إمکانية إستخدام اشارات الخطر Red Flags کإنذار مبکر لإمکانية الکشف عن التعثر المالى بهدف إتخاذ الإجراءات التصحيحية اللآزمة لتجنب الوقوع فى التعثر المالى  والتعرف على مدى ملائمة هذه الإشارات للواقع بهدف رفع کفاءة وقدرة ...
کمال کمال عبد السلام
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Fireworks, flags and signs

Trabalhos em Linguística Aplicada, 2020
In article, Sara Roberts, a former BBC researcher and journalist - currently teacher and writer - offers her own personal impressions of the recent rise of populism in Britain and its effects on Brtitish society, based on her experiences in Oxford, where
Sara Roberts
doaj