Results 41 to 50 of about 26,623 (258)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Physiotherapy students’ assessment of psychosocial yellow flags in low back pain

South African Journal of Physiotherapy, 2007
Background: Low Back Pain (LBP) makes up a large proportion of referrals to physiotherapy worldwide. Thus training in its effective assessment and management is essential.
R. Parker
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Language of the Sea: Flags and Identities in Early Modern Dutch Marine Painting

Early Modern Low Countries, 2020
This article investigates the convergence between early modern Dutch marine painting and contemporaneous political identities and diplomatic conventions.
David Onnekink
doaj   +1 more source

The Use of National Strategic Reference Framework Data in Knowledge Graphs and Data Mining to Identify Red Flags

Data, 2021
Red Flags in fiscal projects are warning signs that may indicate underlying problems with their implementation. In this paper, we present how National Strategic Reference Framework Open Data can be used to take full advantage of semantic web technologies
Charalampos Bratsas, Evangelos Chondrokostas, Kleanthis Koupidis, Ioannis Antoniou   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Data from: Event-based reconstruction of time-resolved centreline deformation of flapping flags [PDF]

This directory contains open-source data and code obtained at the UNFoLD laboratory at EPFL. This code implements a new tracking method for fast deformation of flapping flags using an event-based camera.
Raynaud, Gaétan, Mulleners, Karen
core   +1 more source

Targets to promote swimming between the flags among Australian beachgoers [PDF]

, 2016
Visiting the beach is a popular activity, but the risk of drowning is real. Drownings are preventable, and swimming between the patrol flags can save lives.
Wihardjo, Kylie R., Hyde, Melissa K, Hyde, Melissa, White, Katherine M, White, Katherine M., Hyde, Melissa K., Hamilton, Kyra, Wihardjo, Kylie   +7 more
core   +1 more source

CNS damage biomarkers in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease

Journal of Affective Disorders Reports, 2023
Objective: To describe the prevalence of central nervous system (CNS) pathology in a psychiatric patient cohort enriched for clinical red flags of suspected autoimmune psychiatric disease, we explored associations between CNS damage biomarkers in ...
Janet Cunningham, Mikaela Syk, Emma Tornvind, Maike Gallwitz, David Fällmar, Åsa Amandusson, Holger Rothkegel, Torsten Danfors, Måns Thulin, Annica J. Rasmusson, Simon Cervenka, 1, Tom Pollack, Ludger Tebartz van Elst, Dominique Endres, Robert Bodén, Björn M. Nilsson, Joachim Burman   +16 more
doaj   +1 more source