Results 141 to 150 of about 6,086,816 (288)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Supercapacitor Safety: Overcharge‐Induced Failure Mechanisms in Electrochemical Double‐Layer Capacitors

Advanced Science, EarlyView.
Time‐resolved synchrotron radiography reveals the internal evolution of electrochemical double‐layer capacitors under abusive overcharge. EDLCs are shown to follow a thermally driven failure pathway involving electrolyte decomposition, gas generation, and structural collapse, distinct from chemically driven thermal runaway effects of Lithium‐ion ...
Thomas Dore, Inez Kesuma, Abdus S. Ali, Jonas Pfaff, Yuxiao Jin, Rosalie Hamill, Mark Buckwell, Hamish Reid, Thomas Finco, Zeyu Sun, Yuanze Li, Sebastian Schopferer, Siegfried Nau, Nils Böttcher, Henning Markötter, Alexander J. E. Rettie, James Robinson, Paul R. Shearing, Alexander Rack, Thomas S. Miller   +19 more
wiley   +1 more source

Ablation‐Immune Thermal Armor Via Microstructural‐Compatibility Design for Extreme Thermal Conditions

Advanced Science, EarlyView.
This study unveils a microstructural‐compatibility design strategy that integrates reactive melt infiltration with plasma spraying to fabricate carbon fiber‐reinforced ZrC‐SiC composites. The deliberate incorporation of SiC into the ZrC coating releases heat accumulation, suppresses detrimental lamellar ZrO2 formation, and reduces residual stress. This
Hongkang Ou, Lingxiang Guo, Bing Liu, Ziyi Yi, Yuyu Zhang, Jia Sun, Qiangang Fu   +6 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Physical Approach to the Combustion Process of Polymer Fibre-Based Insulation Materials: An Initial Experimental Study. [PDF]

Polymers (Basel)
Sedlmajer M, Zach J, Peterkova J, Novak V, Korjenic A.   +4 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Study on the Effectiveness of NH₄H₂PO₄ Powder in Inhibiting the Pyrolysis Gas Flame of Coniferous Woods and Its Suppression Mechanism. [PDF]

ACS Omega
Gao J, Zhang K, Li G, Liu K, Chen Y, Lu J, Wang J, Li H, Zhang B.   +8 more
europepmc   +1 more source

Liquidity Risk, Credit Risk and the Overnight Interest Rate Spread: A Stochastic Volatility Modelling Approach [PDF]

In this paper we model the volatility of the spread between the overnight interest rate and the central bank policy rate (the policy spread) for the euro area and the UK during the two main phases of the financial crisis that began in late 2007.
John Beirne, Guglielmo Maria Caporale, Nicola Spagnolo   +2 more
core   +2 more sources

Method of local potential for the prediction of stationary flame spread rate

Vestnik Udmurtskogo Universiteta. Matematika. Mekhanika. Komp'yuternye Nauki, 2010
A.I. Karpov, A.V. Kudrin
openaire   +2 more sources