Results 201 to 210 of about 20,723,496 (219)

Tonoplast‐Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5991-6006, November 2026.
ABSTRACT The plant‐derived specialized metabolite montbretin A (MbA) is under development as an improved treatment for Type 2 diabetes, a worldwide epidemic. MbA is an acylated flavonol glycoside so far only found in small amounts in montbretia (Crocosmia × crocosmiiflora) corms.
Charlotte Hijmans, Filipe Cabrita Cruz, Lars H. Kruse, Joerg Bohlmann, Sandra Irmisch   +4 more
wiley   +1 more source

A Lambda Red Recombinase‐Assisted CRISPR/Cas9 System for Efficient and Precise Genome Editing in Agrobacterium tumefaciens

Plant Biotechnology Journal, Volume 24, Issue 11, Page 6010-6027, November 2026.
ABSTRACT Agrobacterium tumefaciens is a powerful delivery tool for plant genetic transformation and a pivotal platform for agricultural biotechnology. However, laboratory strains of Agrobacterium have remained genetically unoptimized for decades, with genome engineering hindered by inefficient, endogenous homologous recombination systems.
Minmin Zheng, Rui Liu, Wei‐Chang Huang, Zuren Li, Kai Hua   +4 more
wiley   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, Volume 111, Issue 11, Page 5236-5249, 1 November 2026.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Tuning the Triazolotriazine Scaffold Toward Selective A3 Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Veronika Kost, Filippo Prencipe, Federica Panozzi, Veronica Salmaso, Sonja Kachler, Karl‐Norbert Klotz, Elisabetta Coppi, Simone Adorinni, Stefano Moro, Anna Maria Pugliese, Stephanie Federico, Giampiero Spalluto, Tatiana Da Ros   +12 more
wiley   +1 more source

An Immobilized Marine Glycosyltransferase Acts as a Stabilized Biocatalyst for the Synthesis of Mannosylated Phosphoisoprenoids

Advanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.
Mannosylated phosphoisoprenoids are generated by an immobilised glycosyltransferase as a sustainable approach towards the functionalisation of complex molecules. Glycosylated phosphoisoprenoids constitute valuable bioactive molecules and starting materials for complex glycosylation cascades.
Cecilia Ortiz, Ryan D. Packer, Malena Dalies, Manuela Tosin, Lorena Betancor   +4 more
wiley   +1 more source

An Evaluation of the Accuracy of a Flash Glucose Monitoring System in Children with Diabetes in comparison with Venous Blood Glucose. [PDF]

J Diabetes Res, 2019
Cao B, Wang R, Gong C, Wu D, Su C, Chen J, Yi Y, Liu M, Liang X, Li W.   +9 more
europepmc   +1 more source

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Needle-Free Jet Injection of Insulin Glargine Improves Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Study Based on the Flash Glucose Monitoring System

Expert Opinion on Drug Delivery, 2021
Jian-Hua Ma, Rengna Yan, Xiaocen Kong
exaly