Results 41 to 50 of about 171,918 (304)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Large-diameter ceramic room-temperature flash sintering technology based on new carbon electrodes

Journal of Advanced Ceramics
Room-temperature flash sintering (FS) for ceramics is a highly efficient and energy-saving new ceramic sintering technique. Addressing the current challenges in room-temperature flash sintering research, such as small product sizes, shape limitations ...
Zhuo Liu, Zhixing He, Zongjian Li, She Chen, Li Cheng, Xinhao Zhao, Xuetong Zhao, Guilai Yin, Nianping Yan, Jinling Liu, Xilin Wang, Zhidong Jia   +11 more
doaj   +1 more source

Effect of thermal insulation on microstructural homogeneity and onset temperature of flash sintered materials

, 2023
The present work aimed to reduce the microstructure heterogeneity inherent to flash sintering by using alumina blankets as a thermal insulator around ZnO cylindrical samples during the sintering process, under different electric field conditions. Thermal
da Silva, João G. P., Storion, Ana G., Pallone, Eliria M. J. A., Lavagnini, Isabela R., Campos, João V., Maestrelli, Sylma C.   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Flash sintering scaling-up challenges: Influence of the sample size on the microstructure and onset temperature of the flash event

, 2020
The influence of sample size on microstructure, density, and onset temperature of the flash event was investigated for 3 mol% yttria-stabilised zirconia (3YSZ).
Ferreira, Julieta A., Pallone, Eliria M. J. A., Pereira da Silva, Joao Gustavo, Mücke, Robert, Lavagnini, Isabela R., Guillon, Olivier, Campos, João V., Sousa, Rafael V.   +7 more
core   +1 more source

Defect Termination of Flash-Lamp-Crystallized Large-Grain Polycrystalline Silicon Films by High-Pressure Water Vapor Annealing [PDF]

, 2013
High-pressure water-vapor annealing (HPWVA) is performed on 3-µm-thick polycrystalline silicon (poly-Si) films formed on glass substrates by crystallizing electron-beam (EB)-evaporated precursor amorphous Si (a-Si) films by flash lamp annealing (FLA ...
Ohdaira, Keisuke
core   +1 more source

Influence Of Flash Temperature On Exergetical Performance Of Organic Flash Cycle

, 2013
Organic Flash Cycle (OFC) has potential of improving efficiency for recovery of low temperature heat sources mainly due to reducing temperature mismatch in the heat exchanger. In this work exergetical performance analysis of ORC is conducted for recovery of low grade heat source.
Kim, Kyoung Hoon, Han, Chul Ho
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A Method to Evaluate Explosive Crystallization Velocity of Amorphous Silicon Films during Flash Lamp Annealing [PDF]

, 2014
Flash lamp annealing (FLA) of micrometer-order-thick amorphous silicon (a-Si) films can induce explosive crystallization (EC), high-speed lateral crystallization driven by the release of latent heat.
Ohdaira, Keisuke
core   +1 more source