Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Dynamic response of reinforced concrete flat plate substructure test
, 2019 Research on mitigating progressive collapse of reinforced concrete (RC) flat plate structures has gained growing attentions. Based on alternative path method, extensive experimental studies have been conducted to simulate column loss scenarios.
Guan, H, Xu, L, Li, Y, Yang, Z
core
Drag on a smooth flat plate with a fence [PDF]
, 1963 CER63EJP66.December 1963.Includes bibliographical references.Submitted to the Society of Mechanical Engineers for presentation at the Symposium on fully separated flow, Philadelphia, Pennsylvania, April 1964.A method is presented which permits the ...
Fluid Dynamics and Diffusion Laboratory, Colorado State University, publisher +1 more
core
Enrichment of heavy water in flat-plate thermal-diffusion columns with optimal plate aspect ratio
, 2011 The optimum plate aspect ratios for maximum separation of heavy water, maximum production rate and minimum plate surface area in flat-plate thermal-diffusion column with plate surface area fixed, have been determined. Essential improvement in performance
Yeh, Ho-Ming
core +1 more source
Pressure distribution on a flat plate in the context of the phenomenon of the Coanda effect hysteresis. [PDF]
Sci Rep, 2022 Skotnicka-Siepsiak A.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Convective heat transfer correlation for a single surrogate firebrand and a simplified firebrand pile on a flat plate using naphthalene sublimation in heated air flow. [PDF]
Fire Saf J, 2023 Wessies SS, Yang JC.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Journal of Engineering, 2015 The current research illustrates experimentally the effect of series and parallel connection (Z-I Configurations) of flat plate water solar collectors array on the thermal performance of closed loop solar heating system.
Jafar Mehdi Hassan, Prof. Dr. +2 more
doaj
Performance Comparison of Different Flat Plate Solar Collectors by Means of the Entropy Generation Rate Using Computational Fluid Dynamics. [PDF]
Entropy (Basel), 2023 Ramírez-Minguela JJ +6 more
europepmc +1 more source