Results 141 to 150 of about 193,322 (317)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

CFD Simulation of Enhancement Techniques in Flat Plate Solar Water Collectors

مجلة النهرين للعلوم الهندسية, 2017
The present work is a numerical study of thermal performance of modified flat plate solar water collectors. Numerical simulations have been done by solving the governing equations (Continuity, Momentum and Energy) equations in the laminar regime , three ...
Jafar Mehdi Hassan, Qussai J. Abdul-Ghafour, Mohammed F. Mohammed   +2 more
doaj  

Energy, exergy and economic (3E) analysis of flat-plate solar collector using novel environmental friendly nanofluid. [PDF]

Sci Rep, 2023
Amar M, Akram N, Chaudhary GQ, Kazi SN, Soudagar MEM, Mubarak NM, Kalam MA.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis of second grade hybrid nanofluid flow over a stretching flat plate in the presence of activation energy. [PDF]

Sci Rep, 2022
Arif M, Saeed A, Suttiarporn P, Khan W, Kumam P, Watthayu W.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study of transpiration cooling over a flat plate at hypersonic Mach numbers

, 1995
Transpiration cooling over a flat plate at hypersonic Mach numbers is analyzed using Navier-Stokes equations, without the assumption of an isothermal wall with a prescribed wall temperature. A new criterion is proposed for determining a relevant range of
Reddy, NM, Sreekanth , *
core  

Analytical Solution and Analysis of Aerodynamic Noise Induced by the Turbulent Flow Interaction of a Plate with Double-Wavelength Bionic Serration Leading Edges

Biomimetics
As a bionic flow control structure, leading-edge serrations have been proven to effectively suppress the aerodynamic noise of airfoils. Compared with single-wavelength serrations, a greater noise reduction potential can be obtained for airfoils with the ...
Chenye Tian, Xiaomin Liu, Lei Wang, Yuefei Li, Yandong Wu   +4 more
doaj   +1 more source

Thermo-economic and environmental optimization using PSO of solar organic Rankine cycle with flat plate solar collector. [PDF]

Heliyon, 2023
Valencia Ochoa G, Ortiz EV, Forero JD.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source