Results 151 to 160 of about 193,322 (317)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

STUDI PERBANDINGAN ANALISIS FLAT SLAB DAN FLAT PLATE

, 2019
Flat slab dan flat plate merupakan elemen struktur yang  tidak mempuyai balok, dimana seluruh beban yang ada disalurkan oleh pelat  menuju ke kolom.
Pandaleke, Ronny E., Constantine, Fransisca Nikita, Sumajouw, Marthin D. J.   +2 more
core  

Theoretical and Experimental Studies of CO₂ Absorption in Double-Unit Flat-Plate Membrane Contactors. [PDF]

Membranes (Basel), 2022
Ho CD, Chang H, Tu JW, Lim JW, Chiou CP, Chen YJ.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Simple Monodimensional Model for Linear Growth Rate of Photosynthetic Microorganisms in Flat-Plate Photobioreactors

, 2002
The current study proposes a simple monodimensional model to estimate the linear growth rate of photosynthetic microorganisms in flat-plate photobioreactors (FPPBRs) during batch cultivation.
Nag-Jong Kim, Choul-Gyun Lee, In Soo Suh, Byung-Ki Hur, Microorganisms In Flat-plate Photobioreactors   +4 more
core  

Experimental and analytical datasets for pressure drop and flow distribution in a Z-type flat-plate solar absorber. [PDF]

Data Brief, 2022
Shantia A, Streicher W.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Performance evaluation of solar flat plate collector [PDF]

, 2010
Flat Plate Collectors (FPC) is widely used for domestic hot-water, space heating/drying and for applications requiring fluid temperature less than 100oC. The absorber plate of the FPC transfers solar energy to liquid flowing in the tubes.
Nik Mohd Qamarul Shafiq, Nik Ahmad Kamil
core  

Transient Heat Transfer Characteristics in a Flat Plate Heat Sink with Mini-Channels for Cooling High Heat Flux IGBT. [PDF]

Micromachines (Basel), 2022
Chen C, Zhao H, Liu C, Chen J, Liu C, Zhang T, Gong W.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source