Results 71 to 80 of about 193,322 (317)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Rarefied hypersonic flow simulations using the Navier-Stokes equations with non-equilibrium boundary conditions [PDF]

, 2012
This paper investigates the use of Navier-Stokes-Fourier equations with non-equilibrium boundary conditions (BCs) for simulation of rarefied hypersonic flows.
Reese, Jason M., Christopher J. Greenshields, Greenshields, Christopher, Jason M. Reese, Greenshields, Christopher J., Reese, Jason   +5 more
core   +1 more source

A computational study of the aerodynamic performance of a dragonfly forewing in gliding flight

MATEC Web of Conferences, 2018
Gliding flight is a common mode of flight for dragonfly, the objective of the current research is to use numerical simulations to explore whether the corrugations have positive effect on aerodynamic performance of the dragonfly wings in gliding flight ...
Liu Huixiang, He Guoyi, Ma Chengyu, Wang Qi, Luo Yun   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Wide-angle, high-concentration photovoltaics to compete with flat plate systems [PDF]

, 2013
A novel photovoltaic concentrator enables highly uniform irradiance on a small number of efficient solar cells. The maximum electrical power of a photovoltaic (PV) energy installation depends on three factors: the available irradiance, the size of the ...
Benítez Giménez, Pablo, Vilaplana, J., Mohedano, Rubén, Cvetkovic, Aleksandra, Zamora Herranz, Pablo, Miñano Dominguez, Juan Carlos, Hernández Sanz, Maikel   +6 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Numerical Simulation and Experimental Study of Flat Microheat Pipe Radiator for Metro Converter

Zhileng xuebao, 2019
A flat-plate microheat pipe was applied to an IGBT radiator of metro converter, resulting in a new flat-plate microheat pipe radiator design. The mathematical model was established through a reasonable simplification of the physical model.
Mu Fusheng, Wang Haijun, Jiang Lexin, Chen Xiao, Chen Liufa   +4 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dynamic Characteristics and Flow Field Evolution of Flat Plate Water Entry Slamming Based on Smoothed Particle Hydrodynamics

Journal of Marine Science and Engineering
Water entry slamming is a complicated issue in marine engineering, characterized by significant impact loads and complex flow. This paper establishes a 3D numerical model of flat plate water entry slamming based on smoothed particle hydrodynamics (SPH ...
Zhongming Li, Yingfei Zan, Ruinan Guo, Yaogang Sun, Nan Sun   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source