Results 71 to 80 of about 128,614 (280)

Flatness Criteria

Journal of Algebra, 1995
Let \(f : (X,x) \to (Y,y)\) be a morphism of local schemes and \((Z,x)\) the central fiber. The flatness of \(f\) is a subtle geometric notion and it is difficult to find some flatness criteria which do not require infinitesimal properties. A well-known result of \textit{H. Hironaka} [Ill. J. Math.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Varying c and Particle Horizons [PDF]

, 2001
We explore what restrictions may impose the second law of thermodynamics on varying speed of light theories. We find that the attractor scenario solving the flatness problem is consistent with the generalized second law at late time.Comment: Latex file ...
Albrecht, Alejandro S. Jakubi, Bahcall, Balbi, Barrow, Barrow, Barrow, Barrow, Bekenstein, Bond, Chimento, Coleman, Damour, Davies, Davies, Davies, Davies, Diego Pavón, Ellis, Gibbons, Gray, Jaynes, Kostelecky, Lima, Luis P. Chimento, Marciano, Moffat, Moffat, Nordtvedt, Pathria, Pavón, Rowan-Robinson, Tribus, Zimdahl   +33 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Flat building blocks for flat silicene [PDF]

Scientific Reports, 2017
AbstractSilicene is the silicon equivalent of graphene, which is composed of a honeycomb carbon structure with one atom thickness and has attractive characteristics of a perfect two-dimensional π-conjugated sheet. However, unlike flat and highly stable graphene, silicene is relatively sticky and thus unstable due to its puckered or crinkled structure ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Hitchin-Witten Connection and Complex Quantum Chern-Simons Theory [PDF]

, 2014
We give a direct calculation of the curvature of the Hitchin connection, in geometric quantization on a symplectic manifold, using only differential geometric techniques.
Andersen, Jørgen Ellegaard, Gammelgaard, Niels Leth   +1 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Condition Assessment Method of Rail Welded Joint Equipment Based on Confidence Level

Chengshi guidao jiaotong yanjiu
Objective To address the incomplete assessment system for seamless rail equipment conditions in China, it is necessary to establish an equipment condition assessment method for rail welded joints.
Guoxiang MA
doaj   +1 more source

The nonholonomic Riemann and Weyl tensors for flag manifolds [PDF]

, 2005
On any manifold, any non-degenerate symmetric 2-form (metric) and any skew-symmetric (differential) form W can be reduced to a canonical form at any point, but not in any neighborhood: the respective obstructions being the Riemannian tensor and dW.
Dimitry A. Leites, Dimitry Leites, Pavel Grozman, Pavel Grozman, The Nonholonomic Riemann, Weyl Tensors   +5 more
core   +1 more source