Results 71 to 80 of about 15,751 (313)

Surface doses of flattening filter free beams with volumetric modulated arc therapy dose delivery for breast cancer

Physics and Imaging in Radiation Oncology, 2017
Background and purpose: Flattening filter free (FFF) beams enable high-dose rate irradiations and have the potential to speed up breast cancer radiotherapy (RT) treatments.
Jan Seppälä, Aleksi Voutilainen, Janne Heikkilä, Marko Vauhkonen   +3 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Feasibility and early clinical assessment of flattening filter free (FFF) based stereotactic body radiotherapy (SBRT) treatments

Radiation Oncology, 2011
Purpose To test feasibility and safety of clinical usage of Flattening Filter Free (FFF) beams for delivering ablative stereotactic body radiation therapy (SBRT) doses to various tumor sites, by means of Varian TrueBeam™ (Varian Medical Systems). Methods
Ascolese Anna M, Reggiori Giacomo, Pentimalli Sara, Pellegrini Chiara, Palumbo Valentina, Navarria Pierina, Mancosu Pietro, Lobefalo Francesca, Fogliata Antonella, Clivio Alessandro, Castiglioni Simona, Alongi Filippo, Scorsetti Marta, Roggio Antonella, Arcangeli Stefano, Tozzi Angelo, Vanetti Eugenio, Cozzi Luca   +17 more
doaj   +1 more source

Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature

Advanced Healthcare Materials, EarlyView.
Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest, Katherine J. Young, Isabella K. Holtz, Mark Mc Veigh, James D. West, Leon M. Bellan   +5 more
wiley   +1 more source

A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy in nasopharyngeal carcinoma

Journal of Medical Physics, 2014
Purpose: To explore the dosimetric effects of flattening filter-free (FFF) beams in volumetric modulated arc therapy (VMAT) of nasopharyngeal carcinoma via a retrospective planning study.
Guishan Fu, Minghui Li, Yixin Song, Jianrong Dai   +3 more
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Flattening filter-free accelerators: a report from the AAPM Therapy Emerging Technology Assessment Work Group. [PDF]

, 2019
This report describes the current state of flattening filter-free (FFF) radiotherapy beams implemented on conventional linear accelerators, and is aimed primarily at practicing medical physicists.
Stathakis, Sotirios, Papanikolaou, Niko, Xiao, Ying, Yin, Fang-Fang, Huq, Saiful, Kry, Stephen F, Yorke, Ellen, Bayouth, John, Xia, Ping, Galvin, James, Popple, Richard   +10 more
core   +4 more sources

Clinical advantages of using unflattened 6-MV and 10-MV photon beams generated by the medical accelerator Elekta Versa HD based on their dosimetric parameters in comparison to conventional beams

Nukleonika, 2019
Photon beams with wide energy ranges from 4 MV to 25 MV are commonly used in radiotherapy nowadays. In recent years, there has been a strong interest in a certain modification of a radiotherapeutic apparatus by the application of the so-called flattening
Baic Błażej, Kozłowska Beata, Kwiatkowski Robert, Dybek Marcin   +3 more
doaj   +1 more source

Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration

Advanced Materials, EarlyView.
A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang, Byeongseok Ryu, Sujeong Ahn, Junhyub Kim, Myeonghun Jang, Jeong Ho Cho, Won‐Gun Koh, Hyungsuk Lee   +7 more
wiley   +1 more source