Results 31 to 40 of about 3,063 (181)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

International Journal for Parasitology: Drugs and Drug Resistance, 2018
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J. Marks, Aaron G. Maule   +8 more
doaj   +1 more source

Review of the fauna associated with wild and farmed mussels and oysters in the Mediterranean

Biological Reviews, EarlyView.
ABSTRACT Mussels and oysters are important ecosystem engineers which modify the physical and chemical characteristics of the environment and create habitats that support highly diverse associated communities. In the Mediterranean Sea, the native Mediterranean mussel Mytilus galloprovincialis and the European flat oyster Ostrea edulis, together the ...
Barbara Mikac, Marina Antonia Colangelo, Alessandro Tarullo, Marco Abbiati, Eugenio Fossi, Federica Costantini   +5 more
wiley   +1 more source

Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano

eLife, 2016
The regeneration-capable flatworm Macrostomum lignano is a powerful model organism to study the biology of stem cells in vivo. As a flatworm amenable to transgenesis, it complements the historically used planarian flatworm models, such as Schmidtea ...
Magda Grudniewska, Stijn Mouton, Daniil Simanov, Frank Beltman, Margriet Grelling, Katrien de Mulder, Wibowo Arindrarto, Philipp M. Weissert, Stefan van der Elst, Eugene Berezikov   +9 more
doaj   +1 more source

Identification and evolution of nuclear receptors in Platyhelminths.

PLoS ONE, 2021
Since the first complete set of Platyhelminth nuclear receptors (NRs) from Schistosoma mansoni were identified a decade ago, more flatworm genome data is available to identify their NR complement and to analyze the evolutionary relationship of ...
Wenjie Wu, Philip T LoVerde
doaj   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

Live large flatworm in intestine

Pan African Medical Journal, 2021
A 40-year male presented to the emergency department with the complaints of fatigue that had progressively worsened over the period of 3 months. He had recently emigrated from Mexico, where he worked on a farm and eaten raw watercress. Clinical examination revels pallor of oral mucosa.
Medhavi Vivek Joshi, Chaitanya Ajay Kulkarni   +1 more
openaire   +3 more sources

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Pharmacological targeting of glutamate-gated chloride channels (GluCls) is a potent anthelmintic strategy, evidenced by macrocyclic lactones that eliminate numerous roundworm infections by activating roundworm GluCls.
Timothy Lynagh, Brett A. Cromer, Vanessa Dufour, Bodo Laube   +3 more
doaj   +1 more source

Comprehensive Evaluation of Bisphenol A Toxicity Reveals Neurobehavioral, Metabolic, and Reproductive Impairments in Girardia tigrina

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino, Felipe Schaly, Welligton Luciano Braguini   +2 more
wiley   +1 more source

Neurotransmitters of sleep and wakefulness in flatworms

Sleep, 2022
Abstract Study Objectives Sleep is a prominent behavioral and biochemical state observed in all animals studied, including platyhelminth flatworms. Investigations into the biochemical mechanisms associated with sleep—and wakefulness—are important for understanding how these states are regulated and ...
Shauni E T Omond, Matthew W Hale, John A Lesku   +2 more
openaire   +2 more sources