Tetrodotoxin (TTX) as a Therapeutic Agent for Pain [PDF]
Marine Drugs, 2012 Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs). VGSCs play a critical role in neuronal function under both physiological and pathological conditions.
FRANCISCO R Nieto +2 more
exaly +8 more sources
The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates [PDF]
Marine Drugs, 2010 Tetrodotoxin (TTX) is widely distributed in marine taxa, however in terrestrial taxa it is limited to a single class of vertebrates (Amphibia). Tetrodotoxin present in the skin and eggs of TTX-bearing amphibians primarily serves as an antipredator ...
Charles T Hanifin, Hanifin Charles T
exaly +5 more sources
The impact of tetrodotoxin (TTX) on the gut microbiome in juvenile tiger pufferfish, Takifugu rubripes [PDF]
Scientific ReportsAbstractTetrodotoxin (TTX) is a potent neurotoxin that accumulates in Takifugu rubripes, commonly known as pufferfish, through the ingestion of TTX-bearing organisms as part of their food chain. Although researchers believe that pufferfish use TTX to relieve stress, data are not currently available on how TTX affects the gut microbiota of pufferfish ...
Koji Hamasaki +2 more
exaly +5 more sources
Repurposing of thermally stable nucleic-acid aptamers for targeting tetrodotoxin (TTX). [PDF]
Comput Struct Biotechnol J, 2022 Tetrodotoxin (TTX) is a lethal neurotoxin produced by the endosymbiotic bacteria in the gut of puffer fish. Currently, there is no effective and economical method to detect TTX, so it is very interesting to develop low-cost and high-sensitivity detection methods by using nucleic-acid aptamers as the recognition molecules.
Li Y +5 more
europepmc +4 more sources
High Levels of Tetrodotoxin (TTX) in Trumpet Shell Charonia lampas from the Portuguese Coast. [PDF]
Toxins (Basel), 2021 Tetrodotoxin (TTX) is a potent neurotoxin, considered an emerging toxin in Europe where recently a safety limit of 44 µg TTX kg−1 was recommended by authorities. In this study, three specimens of the large gastropod trumpet shell Charonia lampas bought in a market in south Portugal were analyzed using a neuroblastoma cell (N2a) based assay and by LC-MS/
Costa PR +6 more
europepmc +7 more sources
Antinociceptive effects of tetrodotoxin (TTX) in rodents [PDF]
British Journal of Anaesthesia, 2006 Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models.Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice were used in the writhing test.
Shan Lu
exaly +3 more sources
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods. [PDF]
EFSA J, 2017 Tetrodotoxin (TTX) and its analogues are produced by marine bacteria and have been detected in marine bivalves and gastropods from European waters. The European Commission asked EFSA for a scientific opinion on the risks to public health related to the presence of TTX and TTX analogues in marine bivalves and gastropods. The Panel on Contaminants in the
EFSA Panel on Contaminants in the Food Chain (CONTAM) +30 more
europepmc +7 more sources
Identifying environmental factors associated with tetrodotoxin contamination in bivalve mollusks using eXplainable AI [PDF]
npj Science of FoodSince 2012, tetrodotoxin (TTX) has been found in seafoods such as bivalve mollusks in temperate European waters. TTX contamination leads to food safety risks and economic losses, making early prediction of TTX contamination vital to the food industry and
M. C. Schoppema +6 more
doaj +2 more sources
Bibliographic Studies on the Tetrodotoxin(TTX)
Journal of Pharmacopuncture, 2000 We were trying to study the validity of Puffer fish's poison(Tetrodotoxin- TTX) to make a traditional Korean Medical treatment. The following conclusions were made after literary studies. 1.
Hwang, Tae-Joon +2 more
doaj +2 more sources
An Investigation into Tetrodotoxin (TTX) Levels Associated with the Red Dorsal Spots in Eastern Newt (Notophthalmus viridescens) Efts and Adults [PDF]
Journal of Toxicology, 2018 We investigated the concentration of tetrodotoxin (TTX) in sections of skin containing and lacking red dorsal spots in both Eastern newt (Notophthalmus viridescens) efts and adults.
Mackenzie M. Spicer +5 more
doaj +2 more sources