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Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Toxins, 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Alan O'Riordan, Ambrose Furey, Mary Lehane   +2 more
exaly   +3 more sources

Multi-Omics Reveals Tetrodotoxin Transport and Accumulation Mechanisms in Takifugu bimaculatus [PDF]

Marine Drugs
The potent toxicity of tetrodotoxin (TTX) has long constrained sustainable growth in pufferfish aquaculture. Takifugu bimaculatus, an economically important species farmed along the coast of Fujian, China, remains poorly understood regarding how it ...
Xinxin Zhang, Min Xu, Jiapeng Qi, Shuigen Li, Xiaoting Chen, Bei Chen, Shuilin Cai, Kun Qiao, Qilin Huang, Zhiyu Liu   +9 more
doaj   +2 more sources

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
David Harwood, Sarah Finch, Michael J Boundy   +2 more
exaly   +3 more sources

Nanozyme-Based Colorimetric Assay on a Magnetic Microfluidic Platform for Integrated Detection of TTX [PDF]

Biosensors
Tetrodotoxin (TTX) is a potent marine neurotoxin, necessitating sensitive and user-friendly on-site assays. To address long workflows of traditional immunoassays and limited signal amplification in colorimetric microfluidics, we developed a nanozyme ...
Chenqi Zhang, Shuo Wu, Fangzhou Zhang, Chang Chen, Jianlong Zhao, Shilun Feng, Bo Liu   +6 more
doaj   +2 more sources

Survey of Tetrodotoxins (TTXs) in Gastropods, Sea Urchins, and Blue Crabs from the Adriatic Sea: First Report in Paracentrotus lividus [PDF]

Foods
The detection of tetrodotoxins (TTXs) in European shellfish led the European Union to request a risk assessment from the European Food Safety Authority (EFSA).
Simone Bacchiocchi, Melania Siracusa, Giulia Diomedi, Simone Mazza, Erica Calandri, Tamara Tavoloni, Veronica Vivani, Monica Cangini, Giuseppe Arcangeli, Carmen Losasso, Silva Rubini, Gabriella Di Francesco, Francesca Leoni, Arianna Piersanti, Francesca Barchiesi   +14 more
doaj   +2 more sources

Tetrodotoxin [PDF]

Current Biology, 2016
In this Quick Guide, Lorentz et al. discuss the function of tetrodotoxin and its distribution in the animal kingdom.
Max N, Lorentz, Amber N, Stokes, Daniela C, Rößler, Stefan, Lötters   +3 more
openaire   +3 more sources

Molecular Characterization of the Von Willebrand Factor Type D Domain of Vitellogenin from Takifugu flavidus

Marine Drugs, 2021
The von Willebrand factor type D (VWD) domain in vitellogenin has recently been found to bind tetrodotoxin. The way in which this protein domain associates with tetrodotoxin and participates in transporting tetrodotoxin in vivo remains unclear.
Kun Qiao, Caiyun Jiang, Min Xu, Bei Chen, Wenhui Qiu, Yongchang Su, Hua Hao, Zhiyong Lin, Shuilin Cai, Jie Su, Zhiyu Liu, Wenshu Huang   +11 more
doaj   +1 more source

Reversible cerebral vasoconstriction syndrome associated with tetrodotoxin poisoning: A case report

Journal of the American College of Emergency Physicians Open, 2021
An 81‐year‐old woman with a history of hypertension and Alzheimer's disease presented to the emergency department because of impaired consciousness. Physical examination revealed acute progressive generalized flaccid paralysis, hypertension, respiratory ...
Eiichi Kakehi, Makoto Matsumoto, Shohei Taniguchi, Yukinobu Akamatsu, Shigehisa Sakurai, Akane Hirotani, Takafumi Nozaki, Keisuke Shoji, Seiji Adachi, Kazuhiko Kotani, Masami Matsumura   +10 more
doaj   +1 more source

Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Toxins, 2021
Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels.
Rafael González-Cano, M. Carmen Ruiz-Cantero, Miriam Santos-Caballero, Carlos Gómez-Navas, Miguel Á. Tejada, Francisco R. Nieto   +5 more
doaj   +1 more source

Tetrodotoxins in Ribbon Worms Cephalothrix cf. simula and Kulikovia alborostrata from Peter the Great Bay, Sea of Japan

Toxins, 2022
Tetrodotoxin, an extremely potent low-molecular-weight neurotoxin, and its analogues (TTXs) are widely distributed in aquatic and terrestrial ecosystems. Most investigations concerning TTXs have been conducted mainly on puffer fish, octopus, and mollusks,
Anna E. Vlasenko, Timur Yu. Magarlamov
doaj   +1 more source