Results 41 to 50 of about 11,247 (202)

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

5-exo Radical Cyclization onto 3-Alkoxyketimino-1,6-anhydromannopyranoses. Efficient Preparation of Synthetic Intermediates for (−)-Tetrodotoxin

, 2016
Ketoxime ethers at C3 of 1,6-anhydro-β-d-mannopyranose derivatives were found to be useful 5-exo radical traps of alkyl and vinyl radicals generated at a chain tethered to the C2 hydroxyl group, allowing advanced synthetic intermediates for ...
M. D. Paredes (3025353), L. Ozores (3025347), B. Noya (3025350), R. Alonso (3025356)   +3 more
core   +1 more source

Investigations on the Tetrodotoxin Binding Component from Electrically Excitable Tissue [PDF]

, 1974
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. Tetrodotoxin from the Japanese puffer fish was labelled with tritium and purified from the crude mixture obtained.
Benzer, Theodore I.
core   +1 more source

Novel Polyclonal Antibody Raised against Tetrodotoxin Using Its Haptenic Antigen Prepared from 4,9-anhydrotetrodotoxin Reacted with 1,2-Ethaneditiol and Further Reacted with Keyhole Limpet Hemocyanin

Toxins, 2019
A novel polyclonal antibody against tetrodotoxin (TTX) was raised using its haptenic antigen, where 4,9-anhydroTTX was reacted with 1,2-ethanedithiol and this derivative was further reacted with keyhole limpet hemocyanin (KLH).
Shigeru Sato, Suzuka Takaishi, Ko Yasumoto, Shugo Watabe   +3 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Investigating Diet as the Source of Tetrodotoxin in the Grey Side-gilled Sea Slug, Pleurobranchaea maculata [PDF]

, 2014
Pleurobranchaea maculata (grey-side gilled sea slug) was discovered to contain the neurotoxin tetrodotoxin (TTX) in 2009 after a spate of dog poisoning cases on the beaches of Auckland, New Zealand.
Khor, Serena
core  

New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism

Marine Drugs, 2018
The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with ...
Andrew D. Turner, David Fenwick, Andy Powell, Monika Dhanji-Rapkova, Charlotte Ford, Robert G. Hatfield, Andres Santos, Jaime Martinez-Urtaza, Tim P. Bean, Craig Baker-Austin, Paul Stebbing   +10 more
doaj   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Elucidating the Origin of Tetrodotoxin in Pleurobranchaea maculata and Stylochoplana sp. [PDF]

, 2015
Tetrodotoxin (TTX) is an extremely potent neurotoxin that acts by selectively targeting voltage gated sodium channels blocking propagation of action potentials.
Salvitti, Lauren R.
core  

Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?

Marine Drugs, 2018
Tetrodotoxin (TTX), the mode of action of which has been known since the 1960s, is widely used in pharmacology as a specific inhibitor of voltage-gated sodium channels (Nav channels).
César Mattei
doaj   +1 more source