Results 1 to 10 of about 11,510 (261)

Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective

Marine Drugs, 2020
Saxitoxin is an alkaloid neurotoxin originally isolated from the clam Saxidomus giganteus in 1957. This group of neurotoxins is produced by several species of freshwater cyanobacteria and marine dinoflagellates.
Nurul Yuziana Mohd Yusof, Asmat Ahmad, Gires Usup   +2 more
exaly   +4 more sources

Improved Accuracy of Saxitoxin Measurement Using an Optimized Enzyme-Linked Immunosorbent Assay

Toxins, 2019
Paralytic shellfish poisoning (PSP) is precipitated by a family of toxins produced by harmful algae, which are consumed by filter-feeding and commercially popular shellfish.
Brittany M Ott, D Ransom Hardison, Richard Wayne Litaker   +2 more
exaly   +4 more sources

Insights into Alexandrium minutum Nutrient Acquisition, Metabolism and Saxitoxin Biosynthesis through Comprehensive Transcriptome Survey

Biology, 2021
The toxin-producing dinoflagellate Alexandrium minutum is responsible for the outbreaks of harmful algae bloom (HABs). It is a widely distributed species and is responsible for producing paralytic shellfish poisoning toxins.
Muhamad Afiq Akbar, Nurul Yuziana Mohd Yusof, Fathul Karim Sahrani, Gires Usup, Asmat Ahmad, Syarul Nataqain Baharum, Nor Azlan Nor Muhammad, Hamidun Bunawan   +7 more
doaj   +2 more sources

Evolution and Distribution of Saxitoxin Biosynthesis in Dinoflagellates

Marine Drugs, 2013
Numerous species of marine dinoflagellates synthesize the potent environmental neurotoxic alkaloid, saxitoxin, the agent of the human illness, paralytic shellfish poisoning.
Anke Stüken, Russell J S Orr, Shauna A Murray   +2 more
exaly   +3 more sources

Rapid Detection of Saxitoxin Using a Nucleic Acid Aptamer Biosensor Based on Graphene Oxide as a Fluorescence Quencher [PDF]

Toxins
Saxitoxin (STX) is a toxin with paralyzing and lethal properties, necessitating the development of a simple analytical method. This study developed a nucleic acid aptamer biosensor using graphene oxide (GO) as a fluorescence quencher for STX detection ...
Yi Jiao, Liqing Yang, Junping Hao, Yuhang Wen, Jianhua Wang, Hengchao E, Zhiyong Zhao, Yufeng Chen, Xianli Yang   +8 more
doaj   +2 more sources

Temperature Influences the Production and Transport of Saxitoxin and the Expression of sxt Genes in the Cyanobacterium Aphanizomenon gracile

Toxins, 2017
The cyanobacterium Aphanizomenon gracile is the most widely distributed producer of the potent neurotoxin saxitoxin in freshwaters. In this work, total and extracellular saxitoxin and the transcriptional response of three genes linked to saxitoxin ...
Samuel Cirés, Miguel González-Pleiter, Antonio Quesada   +2 more
exaly   +3 more sources

An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions

Marine Drugs, 2013
Marine neurotoxins are natural products produced by phytoplankton and select species of invertebrates and fish. These compounds interact with voltage-gated sodium, potassium and calcium channels and modulate the flux of these ions into various cell types.
Kathleen D Cusick
exaly   +3 more sources

Neurotoxic Alkaloids: Saxitoxin and Its Analogs [PDF]

Marine Drugs, 2010
Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of paralytic shellfish poisoning (PSP) and are mostly associated with marine dinoflagellates (eukaryotes) and freshwater cyanobacteria (prokaryotes), which form extensive blooms ...
Maria Wiese, Paul Michael D'Agostino, Brett A Neilan   +2 more
exaly   +5 more sources

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
Sarah C. Finch, Michael J. Boundy, D. Tim Harwood   +2 more
doaj   +2 more sources

Two new skeletal analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic shellfish toxins

Chemosphere, 2021
Satoshi Numano, Yuta Kudo, Yuko Cho
exaly   +2 more sources