Results 21 to 30 of about 26,899 (190)

Stereocontrolled Total Synthesis of Tetrodotoxin from Inositol and D-Glucose by Three Routes: Aspects for Constructing Complex Multi-Functionalized Cyclitols with Branched-Chain Structures

Natural Product Communications, 2013
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative tetrodotoxin containing eight asymmetric carbons and different types of branched-chains from myo -inositol and D-glucose using three different ...
Ken-ichi Sato, Shoji Akai, Juji Yoshimura   +2 more
doaj   +1 more source

Preliminary Results on the Evaluation of the Occurrence of Tetrodotoxin Associated to Marine Vibrio spp. in Bivalves from the Galician Rias (Northwest of Spain)

Marine Drugs, 2018
Tetrodotoxins (TTX) are a potent group of natural neurotoxins putatively produced by symbiotic microorganisms and affecting the aquatic environment. These neurotoxins have been recently found in some species of bivalves and gastropods along the European ...
Jose Manuel Leão, Antonio Lozano-Leon, Jorge Giráldez, Óscar Vilariño, Ana Gago-Martínez   +4 more
doaj   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body

Marine Drugs, 2011
Carotid bodies (CBs) are secondary sensory receptors in which the sensing elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic hypoxia).
Constancio Gonzalez, Ana Obeso, Ana Isabel Caceres, Asuncion Rocher   +3 more
doaj   +1 more source

Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia

Marine Drugs, 2011
Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia.
Christina Bognet, Gabriel Corfas, David Zurakowski, Charles B. Berde, Barak Yahalom, Umeshkumar Athiraman   +5 more
doaj   +1 more source

Analysis of tetrodotoxin poisoning events in China from 2011 to 2020

Zhongguo shipin weisheng zazhi
ObjectiveTo analyze the epidemiological characteristics of tetrodotoxin poisoning events in China from 2011 to 2020 and provide a scientific basis for precise measures to prevent and control tetrodotoxin poisoning.MethodsDescriptive epidemiological ...
LIANG Junhua, HUANG Zheng, GUO Yunchang, FU Ping, LI Liefei, CHEN Lili, LI Ning, FAN Penghui, WEN Jian, LIU Jikai   +9 more
doaj   +1 more source

A Stereoselective Synthesis of (−)-Tetrodotoxin [PDF]

Journal of the American Chemical Society, 2003
An asymmetric synthesis of the fugu fish poison, (-)-tetrodotoxin, is described. The route to this extraordinary target employs a number of unique transformations, foremost of which are two stereospecific C-H bond functionalization reactions. Accordingly, Rh-catalyzed carbene and nitrene C-H insertions facilitate rapid entry to the cyclohexane core of ...
Andrew, Hinman, J, Du Bois
openaire   +2 more sources

Tetrodotoxin Retention in the Toxic Goby Yongeichthys criniger

Journal of Marine Science and Engineering, 2022
To investigate tetrodotoxin (TTX) retention by the toxic goby Yongeichthys criniger, rearing experiments feeding nontoxic diets were conducted using 12 (Group I) and 17 (Group II) specimens collected from a natural environment.
Ryohei Tatsuno, Miwako Shikina, Yuta Yamamoto, Yoko Kanahara, Tomohiro Takatani, Osamu Arakawa   +5 more
doaj   +1 more source

Puffer Fish Gut Microbiota Studies Revealed Unique Bacterial Co-Occurrence Patterns and New Insights on Tetrodotoxin Producers

Marine Drugs, 2020
Tetrodotoxin (TTX) is a potent neurotoxin isolated mainly from toxic puffer fish. To date, the TTX biosynthetic mechanism inside its hosts remains unresolved.
Zhenchi Li, Jinglin Tian, Yukun Lai, Chiu-Hong Lee, Zongwei Cai, Chun-Fai Yu   +5 more
doaj   +1 more source

Investigating Diet as the Source of Tetrodotoxin in Pleurobranchaea maculata

Marine Drugs, 2013
The origin of tetrodotoxin (TTX) is highly debated; researchers have postulated either an endogenous or exogenous source with the host accumulating TTX symbiotically or via food chain transmission.
Serena Khor, Susanna A. Wood, Lauren Salvitti, David I. Taylor, Janet Adamson, Paul McNabb, Stephen Craig Cary   +6 more
doaj   +1 more source