Results 11 to 20 of about 26,870 (181)
Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?
Toxins, 2021 Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels.
Rafael González-Cano +5 more
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Toxins, 2022 Tetrodotoxin, an extremely potent low-molecular-weight neurotoxin, and its analogues (TTXs) are widely distributed in aquatic and terrestrial ecosystems. Most investigations concerning TTXs have been conducted mainly on puffer fish, octopus, and mollusks,
Anna E. Vlasenko, Timur Yu. Magarlamov
doaj +1 more source
6-Nitrodopamine Is the Most Potent Endogenous Positive Inotropic Agent in the Isolated Rat Heart
Life, 2023 Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine.
José Britto-Júnior +9 more
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From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic
Toxins, 2021 Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli +5 more
doaj +1 more source
Marine Drugs, 2006 : Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms.
C. Ruben, Shana L. Geffeney
doaj +1 more source
Marine Drugs, 2022 Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in ...
Shana L. Geffeney +3 more
doaj +1 more source
Marine Drugs, 2012 Tetrodotoxin (TTX) is a potent neurotoxin that has been identified in a range of phylogenetically unrelated marine and terrestrial organisms. Tetrodotoxin was recently detected in New Zealand in Pleurobranchaea maculata (the grey side-gilled sea slug ...
Stephen Craig Cary +5 more
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Marine Drugs, 2022 Tetrodotoxin (TTX) is a potent neurotoxin naturally occurring in terrestrial and marine organisms such as pufferfish. Due to the risk of TTX poisoning, fish of Tetraodontidae family and other puffer-related species must not be placed in the EU markets ...
Miguel Baptista +3 more
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First Detection of Tetrodotoxins in the Cotylean Flatworm Prosthiostomum trilineatum
Marine Drugs, 2021 Several polyclad flatworm species are known to contain high levels of tetrodotoxin (TTX), but currently TTX-bearing flatworms seem to be restricted to specific Planocera lineages belonging to the suborder Acotylea.
Rei Suo +8 more
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Tetrodotoxin. VII. On the Structures of Tetrodotoxin and its Derivatives
Chemical and Pharmaceutical Bulletin, 1964 The structures of both tetrodonic acid hydrobromide and 6, 11-diacetylanhydrotetrodotoxin hydroiodide were established by chemical and X-ray crystallographical research. Based upon structures of both these salts and upon other chemical information, we determined that tetrodotoxin and anhydrotetrodotoxin have zwitterionic hemilactal structures.
Tsuda, Kyosuke +6 more
openaire +3 more sources