Results 11 to 20 of about 26,899 (190)

6-Nitrodopamine Is the Most Potent Endogenous Positive Inotropic Agent in the Isolated Rat Heart

Life, 2023
Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine.
José Britto-Júnior, Lincoln Rangel Medeiros-Teixeira, Antonio Tiago Lima, Letícia Costa Dassow, Rodrigo Álvaro Brandão Lopes-Martins, Rafael Campos, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, Gilberto De Nucci   +9 more
doaj   +1 more source

From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic

Toxins, 2021
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli, Maren Lechner, Audrey Fontes, Lee B. Kats, Heather L. Eisthen, H. Bradley Shaffer   +5 more
doaj   +1 more source

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

Marine Drugs, 2006
: Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms.
C. Ruben, Shana L. Geffeney
doaj   +1 more source

In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

Marine Drugs, 2022
Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in ...
Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin   +3 more
doaj   +1 more source

Tetrodotoxin Concentrations in Pleurobranchaea maculata: Temporal, Spatial and Individual Variability from New Zealand Populations

Marine Drugs, 2012
Tetrodotoxin (TTX) is a potent neurotoxin that has been identified in a range of phylogenetically unrelated marine and terrestrial organisms. Tetrodotoxin was recently detected in New Zealand in Pleurobranchaea maculata (the grey side-gilled sea slug ...
Stephen Craig Cary, Susanna A. Wood, Janet Adamson, Paul McNabb, Jarrod Walker, David I. Taylor   +5 more
doaj   +1 more source

Does Ocean Sunfish Mola spp. (Tetraodontiformes: Molidae) Represent a Risk for Tetrodotoxin Poisoning in the Portuguese Coast?

Marine Drugs, 2022
Tetrodotoxin (TTX) is a potent neurotoxin naturally occurring in terrestrial and marine organisms such as pufferfish. Due to the risk of TTX poisoning, fish of Tetraodontidae family and other puffer-related species must not be placed in the EU markets ...
Miguel Baptista, Ana Catarina Braga, Rui Rosa, Pedro Reis Costa   +3 more
doaj   +1 more source

First Detection of Tetrodotoxins in the Cotylean Flatworm Prosthiostomum trilineatum

Marine Drugs, 2021
Several polyclad flatworm species are known to contain high levels of tetrodotoxin (TTX), but currently TTX-bearing flatworms seem to be restricted to specific Planocera lineages belonging to the suborder Acotylea.
Rei Suo, Maho Kashitani, Hikaru Oyama, Masaatsu Adachi, Ryota Nakahigashi, Ryo Sakakibara, Toshio Nishikawa, Haruo Sugita, Shiro Itoi   +8 more
doaj   +1 more source

Tetrodotoxin. VII. On the Structures of Tetrodotoxin and its Derivatives

Chemical and Pharmaceutical Bulletin, 1964
The structures of both tetrodonic acid hydrobromide and 6, 11-diacetylanhydrotetrodotoxin hydroiodide were established by chemical and X-ray crystallographical research. Based upon structures of both these salts and upon other chemical information, we determined that tetrodotoxin and anhydrotetrodotoxin have zwitterionic hemilactal structures.
Tsuda, Kyosuke, Ikuma, Susumu, Kawamura, Masaaki, Tachikawa, Ryuji, Sakai, Kiyoshi, Tamura, Chihiro, Amakasu, Osamu   +6 more
openaire   +3 more sources

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity

Frontiers in Neuroanatomy, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Chang-Lu Tao, Chang-Lu Tao, Chang-Lu Tao, Yun-Tao Liu, Yun-Tao Liu, Yun-Tao Liu, Z. Hong Zhou, Z. Hong Zhou, Z. Hong Zhou, Z. Hong Zhou, Pak-Ming Lau, Pak-Ming Lau, Pak-Ming Lau, Guo-Qiang Bi, Guo-Qiang Bi, Guo-Qiang Bi, Guo-Qiang Bi   +16 more
doaj   +1 more source

Stereocontrolled Total Synthesis of Tetrodotoxin from -Inositol and D-Glucose by Three Routes: Aspects for Constructing Complex Multi-Functionalized Cyclitols with Branched-Chain Structures

Natural Product Communications, 2015
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative, tetrodotoxin, containing eight asymmetric carbons and different types of branched-chains, from myo -inositol and D-glucose using three different ...
Ken-Ichi Sato, Shoji Akai, Juji Yoshimura   +2 more
doaj   +1 more source