Evaluation of Toxicity Equivalency Factors of Tetrodotoxin Analogues with a Neuro-2a Cell-Based Assay and Application to Puffer Fish from Greece [PDF]
Marine Drugs, 2023 Tetrodotoxin (TTX) is a potent marine neurotoxin involved in poisoning cases, especially through the consumption of puffer fish. Knowledge of the toxicity equivalency factors (TEFs) of TTX analogues is crucial in monitoring programs to estimate the ...
Mounira Alkassar +2 more
exaly +7 more sources
First Report of Two Gymnodimines and Two Tetrodotoxin Analogues in Invertebrates from the North Atlantic Coast of Spain [PDF]
Marine Drugs, 2023 Gymnodimine D (GYM D), 16-desmethyl gymnodimine D (16-desmethyl GYM D), and two tetrodotoxin analogues have been found in invertebrates obtained from the north Atlantic coast of Spain from May 2021 to October 2022.
Araceli E. Rossignoli +3 more
doaj +4 more sources
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods [PDF]
EFSA Journal, 2017 Tetrodotoxin (TTX) and its analogues are produced by marine bacteria and have been detected in marine bivalves and gastropods from European waters. The European Commission asked EFSA for a scientific opinion on the risks to public health related to the ...
EFSA Panel on Contaminants in the Food Chain (CONTAM) +30 more
doaj +10 more sources
Chemical properties and biological activities of three highly purified major tetrodotoxin analogues [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesTetrodotoxin (TTX), the pufferfish toxin, has the potential to cause fatal food poisoning because of its potent voltage-gated sodium channel (Nav) blocking activity.
Mari YOTSU-YAMASHITA +7 more
doaj +5 more sources
Tetrodotoxin and Its Analogues (TTXs) in the Food-Capture and Defense Organs of the Palaeonemertean Cephalothrix cf. simula [PDF]
ToxinsTetrodotoxin (TTX), an extremely potent low-molecular-weight neurotoxin, is widespread among marine animals including ribbon worms (Nemertea). Previously, studies on the highly toxic palaeonemertean Cephalothrix cf.
Grigorii V. Malykin +2 more
doaj +4 more sources
Public Health Risks Associated with Tetrodotoxin and Its Analogues in European Waters: Recent Advances after The EFSA Scientific Opinion [PDF]
Toxins, 2019 Tetrodotoxin (TTX) and its analogues are naturally occurring toxins responsible worldwide for human intoxication cases and fatalities, mainly associated with pufferfish consumption. In the last decade, TTXs were detected in marine bivalves and gastropods
Panagiota Katikou
exaly +5 more sources
Selective Blocking Effects of 4,9-Anhydrotetrodotoxin, Purified from a Crude Mixture of Tetrodotoxin Analogues, on NaV1.6 Channels and Its Chemical Aspects [PDF]
Marine Drugs, 2015 Tetrodotoxin (TTX) is a potent neurotoxin found in a number of marine creatures including the pufferfish, where it is synthesized by bacteria and accumulated through the food chain.
Noriyoshi Teramoto, Mari Yotsu-Yamashita
doaj +5 more sources
New Vectors of TTX Analogues in the North Atlantic Coast: The Edible Crabs Afruca tangeri and Carcinus maenas [PDF]
Marine Drugs, 2023 Tetrodotoxin (TTX) and its analogues are naturally occurring toxins historically responsible for human poisoning fatalities in Eastern Asia. It is typically linked to the consumption of pufferfish and, to a lesser extent, marine gastropods and crabs.
Sandra Lage +3 more
doaj +2 more sources
Tetrodotoxins in Ribbon Worms Cephalothrix cf. simula and Kulikovia alborostrata from Peter the Great Bay, Sea of Japan [PDF]
Toxins, 2022 Tetrodotoxin, an extremely potent low-molecular-weight neurotoxin, and its analogues (TTXs) are widely distributed in aquatic and terrestrial ecosystems. Most investigations concerning TTXs have been conducted mainly on puffer fish, octopus, and mollusks,
Anna E. Vlasenko, Timur Yu. Magarlamov
doaj +2 more sources
Assessing the Toxicity of Lagocephalus sceleratus Pufferfish from the Southeastern Aegean Sea and the Relationship of Tetrodotoxin with Gonadal Hormones [PDF]
Marine Drugs, 2023 Given the dramatic increase in the L. sceleratus population in the southeastern Aegean Sea, there is growing interest in assessing the toxicity of this pufferfish and the factors controlling its tetrodotoxin (TTX) content.
Thekla I. Anastasiou +5 more
doaj +2 more sources