Results 41 to 50 of about 3,742 (170)

Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn. [PDF]

PLoS ONE, 2012
BACKGROUND: DrTx(1-42) (a carboxyl-terminally truncated version of drosotoxin) is a potent and selective blocker of tetrodotoxin-resistant (TTX-R) Na(+) channels in rat dorsal root ganglion neurons with analgesic activity. This purpose is to identify key
Ping Li, Shunyi Zhu
doaj   +1 more source

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis [PDF]

, 2014
In the canon of reactions available to the organic chemist engaged in total synthesis, the Diels–Alder reaction is among the most powerful and well understood. Its ability to rapidly generate molecular complexity through the simultaneous formation of two
Albrecht, Alder, Allred, Arth, Arth, Banville, Barborak, Barcan, Benfey, Berson, Beyler, Beyler, Birch, Birch, Bliese, Blouin, Boezio, Boisvert, Botha, Brener, Brieger, Brogden, Brubaker, Bruce, Bryskier, Butenandt, Cassayre, Chen, Chu-Moyer, Cole, Comini, Corey, Corey, Courchesne, Danishefsky, Davies, Davies, Davies, Dickinson, Diels, Eaton, Eaton, Eaton, Fernández, Fieser, Fleming, Forman, Fu, Gates, Gates, Gates, Gates, Gates, Grieco, Grunwell, Gulland, Gulland, Harrowven, Heckrodt, Heckrodt, Heusler, Hu, Hudlický, Ichihara, Iio, Inubushi, Johns, Kagan, Karlsson, Kende, Kim, Kishi, Kishi, Kishi, Kishi, Kishi, Konno, Kozmin, Kreis, Kummer, Kuttruff, Lang, Layton, Lee, Lukes, Lukes, Magnus, Majetich, Majetich, Marsault, Mehta, Mehta, Mikami, Morales, Mulzer, Nagaoka, Nawrat, Nawrat, Nawrat, Nicolaou, Nicolaou, Nicolaou, Nicolaou, Núñez Montoya, O’Brien, Paquette, Parvez, Pearlman, Perri, Pettit, Podlesny, Podlesny, Poos, Poos, Poos, Presset, Rajapaksa, Rasapalli, Rasapalli, Robinson, Roche, Rodríguez, Rodríguez, Rodríguez, Rodríguez, Rodríguez, Roush, Ruzicka, Sallay, Sarett, Sarett, Sarett, Savard, Sha, Shen, Singh, Smith, Snyder, Speziale, Stork, Stork, Stork, Todd, Trost, Uesaka, von Euler, Waizumi, White, Woodward, Woodward, Woodward, Woodward, Woodward, Woodward, Yamada, Yamaguchi, Yar, Yates, Zanoni, Zincke   +159 more
core   +2 more sources

A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block [PDF]

, 2007
Voltage-gated sodium channels control the upstroke of the action potential in excitable cells of nerve and muscle tissue, making them ideal targets for exogenous toxins that aim to squelch electrical excitability.
Ahern, Christopher A., Dougherty, Dennis A., Eastwood, Amy L., Horn, Richard, Santarelli, Vincent P.   +4 more
core   +2 more sources

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]

, 2014
Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B., Ferreres, Federico, Grosso, Clara, Valentão, Patricia   +3 more
core   +2 more sources

Marine tetrodotoxin as a risk for human health

Journal of Veterinary Research, 2019
Tetrodotoxin (TTX) is a toxin mainly occurring naturally in contaminated puffer fish, which are a culinary delicacy in Japan. It is also detected in various marine organisms like globefish, starfish, sunfish, stars, frogs, crabs, snails, Australian blue ...
Madejska Anna, Michalski Mirosław, Osek Jacek   +2 more
doaj   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon. [PDF]

The Journal of Physiology, 1982
1. The actions of three saxitoxin (STX) analogues have been studied on the frog sartorius muscle fibre and the squid giant axon. One‐‐neosaxitoxin‐‐is a natural analogue, and two‐‐decarbamylsaxitoxin and reduced saxitoxin‐‐are synthetic. 2. The maximum dV/dt of the action potential in paired‐muscle protocol is reduced by the analogues with relative ...
C Y, Kao, S E, Walker
openaire   +2 more sources

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Tetrodotoxin and Its Analogues in the Pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A Comparison of Their Toxin Profiles with the Same Species from Okinawa, Japan

Toxins, 2015
Pufferfish poisoning has not been well documented in the South Pacific, although fish and other seafood are sources of protein in these island nations. In this study, tetrodotoxin (TTX) and its analogues in each organ of the pufferfish Arothron hispidus ...
Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita   +4 more
doaj   +1 more source

Spider neurotoxins targeting voltage-gated sodium channels [PDF]

, 2005
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
core   +1 more source