Results 61 to 70 of about 1,729 (152)

Tetrodotoxin and saxitoxin in two native species of puffer fish, Sphoeroides marmoratus and Lagocephalus lagocephalus, from NE Atlantic Ocean (Madeira Island, Portugal)

, 2019
The presence in EU waters of invasive tetrodotoxin (TTX) -harbouring puffer fishes has been receiving increasingly attention due to potential new threats posed by this potent neurotoxin.
Reis Costa, Pedro, Timoteo, Viriato, Rodrigues, Susana Margarida, Gouveia, Neide, Pinto, Estefania Pereira   +4 more
core   +1 more source

Biosensors for Biotoxins Detection and Monitoring

Advanced Sensor Research, Volume 5, Issue 6, June 2026.
This review examines state‐of‐the‐art biosensing platforms for biotoxin detection, including antibody‐, aptamer‐, CRISPR‐, nanopore‐, whole cells‐ and MIP‐based sensors. It highlights advances in ultra‐sensitive detection, real‐matrix validation in food and water, and multiplexed analysis, and discusses how the integration with machine learning ...
Alissa Agerova, Juan Francisco Bada Juarez, Matteo Dal Peraro   +2 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Cholesterol and Cholesterol‐Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Cholesterol, steroid hormones, and cholesterol‐based imidazolium salts (CHIMs) inhibit Kv7.2/Kv7.3 channels. Notably, NBD‐tagged CHIM‐L enhances currents. These findings demonstrate that both chemical modifications and linker length differentially modulate Kv7 activity, revealing variant‐specific sensitivities and potential pharmacological targets for ...
Elif Karabatak, Ronewa Nematswerani, Vivian Meiritz, Nicole Rychlik, Guiscard Seebohm, Frank Glorius, Thomas Budde   +6 more
wiley   +1 more source

Tetrodotoxin in marine bivalves and edible gastropods: A mini-review

, 2019
Tetrodotoxin (TTX) is a potent neurotoxin responsible for countless human intoxications and deaths around the world. The distribution of TTX and its analogues is diverse and the toxin has been detected in organisms from both marine and terrestrial ...
Biessy, Laura, Hawes, Ian, Harwood, D Tim, Boundy, Michael J, Wood, Susanna, Smith, Kirsty F   +5 more
core   +1 more source

Synthesis of Levoglucosenone‐Based Amphiphilic Molecules via Microwave‐Assisted Michael Additions

Chemistry–Methods, Volume 6, Issue 6, June 2026.
Comparison between the conventional and the sustainable synthetic microwave‐based approach for Michael addition reactions on LGO developed in this work. Aligning with the objectives of the EU chemicals strategy for sustainability, an ultrarapid, safe and sustainable method for producing a library of levoglucosenone (LGO)‐based amphiphilic molecules was
Maria Jose Calandri, Barbara Benedetti, Léa Charrier, Dinis O. Abranches, James R. Sherwood, Gareth O. Lloyd, João A. P. Coutinho, Con Robert McElroy, Alessandro Pellis   +8 more
wiley   +1 more source

Rapid screening and multi-toxin profile confirmation of tetrodotoxins and analogues in human body fluids derived from a puffer fish poisoning incident in New Caledonia [PDF]

, 2017
In August 2014, a puffer fish poisoning incidence resulting in one fatality was reported in New Caledonia. Although tetrodotoxin (TTX) intoxication was established from the patients' signs and symptoms, the determination of TTX in the patient's urine ...
Flores, Cintia, Michael J. Boundy, Cintia Flores, Claude Maillaud, Elliott, Christopher T., Josep Caixach, Sandra Leonardo, Campbell, Katrina, Campàs, Mònica, Yann Barguil, Christopher T. Elliott, Rambla-Alegre, Maria, Harwood, D. Tim, Maillaud, Claude, Maria Rambla-Alegre, Mònica Campàs, Boundy, Michael J., Barguil, Yann, Katrina Campbell, Campbell, Katrina; id_orcid, Diogène, Jorge, D. Tim Harwood, Caixach, Josep, Leonardo, Sandra, Jorge Diogène   +24 more
core   +1 more source

Effects of saxitoxin analogues and ligand competition on sodium currents of squid axons

, 1986
Saxitoxin (STX) and several STX analogues from dinoflagellates (genus Protogonyaulax) block sodium conductance in squid giant axons with variable potencies.
S. Hall, M. S. Brodwick, D. C. Eaton, A. M. Frace   +3 more
core   +1 more source

Tissue-Specific Distribution of Tetrodotoxin (TTX) and Its Analogues in the Blue-Lined Octopus Hapalochlaena fasciata Hoyle 1886 Collected from Jeju Island, Korea using LC-MS/MS

Endemic to southern Australia, the highly venomous octopus Hapalochlaena fasciata has extended its distribution range to temperate areas including Korea, raising concern for potential poisoning risks associated with consuming or encountering these ...
Lee, Jihyun, Hong, Hyun-Ki, Kim, Hyoun Joong, Kajino, Nobuhisa, Kim, Tae Ho, Choi, Kwang-Sik, Park, Bong Ki, Shin, Jong-Seop   +7 more
core   +1 more source