Results 71 to 80 of about 3,742 (170)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Generation of integration-free neural progenitor cells from cells in human urine [PDF]

, 2013
Human neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs).
AS Yoo, B Liao, BA Reynolds, Baojian Liao, BY Hu, BY Hu, C Sheng, Dajiang Qin, Duanqing Pei, DW Han, EY Son, F Lluis, F Soldner, G Pan, Guangjin Pan, H Liu, Haitao Wang, Huanxing Su, IH Park, J Hao, J Kim, J Yu, J Yu, J Yu, JJ Breunig, Jufang He, K Aboody, K Takahashi, K Takahashi, K Watanabe, KL Ring, Kwok Fai So, L Qiang, Lihui Wang, Linli Wang, M Caiazzo, M Thier, MA Esteban, MA Esteban, MA Israel, P Huang, Q Zhou, QL Ying, R Ambasudhan, S Sekiya, T Burdon, T Vierbuchen, T Zhou, TE Ludwig, Wenhao Huang, Wutian Wu, X Zhang, Xichen Bao, Y Buganim, Y Shi, Yanting Xue, Zhenghui Su   +56 more
core   +1 more source

Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum

Glia, Volume 74, Issue 6, June 2026.
Progressive myelin development in mouse corpus callosum is accompanied by gradual decrease in oligodendrocyte precursor cell density and increase in oligodendrocyte density. Pro‐Capase‐3 is transiently upregulated in oligodendrocyte during postnatal development.
Hayes Johnson, Maren Beall, Sophia Latifi, Juan Peng, Wenjing Sun   +4 more
wiley   +1 more source

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. [PDF]

, 2015
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke of the action potential (AP).
Abdulla, Abrahamsen, Abriel, Abriel, Abriel, Abriel, Akopian, Akopian, Akopian, Aley, Aley, Amaya, Arévalo, Bair, Basbaum, Battaini, Ben-Johny, Bendahhou, Beneski, Bennett, Bennett, Berta, Bierhaus, Bierhaus, Bird, Bird, Biswas, Black, Black, Black, Bongiorno, Bouhassira, Bretin, Brouwer, Brower, Brüggemann, Cachemaille, Campbell, Cang, Cantrell, Cantrell, Casals-Diaz, Catterall, Catterall, Cesare, Cesare, Chahine, Chatelier, Chattopadhyay, Chen, Chen, Cheng, Chi, Ciechanover, Coggeshall, Cohen, Costa, Costa, Coward, Coward, Cox, Cronin, Cummins, Cummins, Cummins, Cusdin, Daemen, Dascal, Decosterd, Deribe, Deschênes, Deval, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dietrich, Dina, Dina, Djouhri, Dogrul, Dong, Duan, Dubin, Dustrude, Edinger, Ednie, England, Errington, Errington, Faber, Faber, Fahmi, Ferrari, Ferreira, Ferreira, Fertleman, Firsov, Fitzgerald, Fjell, Fotia, Fotia, Fukuoka, Fukuoka, Galan, Gasser, Gaudet, Gee, Gershon, Gold, Gold, Gold, Goldin, Gould, Gudes, Han, Heikamp, Henry, Herzog, Herzog, Hirade, Hiruma, Ho, Hockley, Hoeijmakers, Hoeijmakers, Huang, Hucho, Hudmon, Hunter, Ikeda, Inagaki, Isom, Isom, Isom, James, Jarecki, Jarvis, Ji, Ji, Jin, Joazeiro, Johnson, Johnson, Joshi, Julius, Kazarinova-Noyes, Kazen-Gillespie, Kerr, Khasar, Khasar, Khasar, Kim, Kispersky, Klugbauer, Kreegipuu, Kresge, Kress, Kretschmer, Kruger, Laedermann, Laedermann, Laedermann, Laedermann, Lai, Latremoliere, Leipold, Leo, Leung, Li, Liang, Liu, Liu, Liu, Liu, Liu, Lolignier, Lopez-Santiago, Lopez-Santiago, Lou, Luo, Luo, Maingret, Malhotra, Malhotra, Maltsev, Mann, Mao, Matzner, Matzner, Messner, Metzger, Millan, Minett, Mittmann, Moon, Moremen, Morgan, Mori, Murphy, Murray, Nagasako, Narayanan, Nassar, Nelson, Noda, Novella, Numann, Nuss, Obata, Olsson, Payandeh, Perry, Persson, Pertin, Petho, Pickart, Pierre, Pitchford, Plummer, Priest, Qu, Rang, Ranscht, Raymond, Recio-Pinto, Ren, Renganathan, Renganathan, Ritchie, Rossie, Rossier, Rush, Rush, Rush, Sadamasu, Sangameswaran, Sanna, Schaller, Schepelmann, Schild, Schirmeyer, Schmidt, Schmidt, Scholz, Shah, Shao, Shi, Shih, Smith, Smith, Snyder, Snyder, Solà, Souza, Stamboulian, Staub, Strickland, Stucky, Sun, Suter, Taiwo, Tan, Thakor, Theriault, Thornalley, Toledo-Aral, Toledo-Aral, Tong, Toth, Turk, Tyrrell, van Bemmelen, Vanoye, Vijayaragavan, Vijayaragavan, Vijayaragavan, von Hehn, Wada, Wada, Waechter, Wang, Waxman, Waxman, Waxman, Waxman, Way, Wells, Widmann, Woolf, Woolf, Woolf, Woolf, Woolf, Wu, Xu, Xu, Xu, Xu, Yan, Yanagita, Yanagita, Yang, Yeomans, Yin, Young, Yu, Yu, Yuhi, Zhang, Zhang, Zhang, Zhang, Zhou, Zhou, Zhuang, Zimmer, Zochodne   +318 more
core   +2 more sources

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Cancer: A bioelectric disease?

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The membrane potential (Vm) has emerged as a systems‐level regulator of cancer cell behaviour, linking ion channel activity to processes such as proliferation, differentiation and therapeutic response. This framework provides a roadmap for translating Vm measurement and validation into bioelectric precision medicine, integrating multi‐omics and ...
Celine Desoyer, Roko Šupe, Sahar Ghorbanpour, Debkalpa Goswami, Mina Khalaj, Nazanin Karami, Dagmar Brislinger, Charlotte A. E. Hauser, Christian Baumgartner   +8 more
wiley   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1162-1180, May 2026.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source